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  • Book
    Rose Utley, Kristina Henry, Lucretia Smith.
    Contents:
    Understanding theoretical concepts / Rose Utley
    Strategies for using frameworks / Rose Utley
    The relationship between theory, research, and practice / Lucretia Smith
    Frameworks for behavioral change / Kristina Henry
    Care and caring frameworks / Rose Utley
    Human development frameworks / Rose Utley
    Frameworks for teaching and learning / Rose Utley
    Moral and ethical perspectives / Rose Utley
    Health and illness frameworks / Lucretia Smith
    Interpersonal and family frameworks / Kristina Henry, Lucretia Smith
    Needs-based frameworks / Rhea Faye D. Felicilda-Reynaldo, Lucretia Smith
    Physiological frameworks / Lucretia Smith
    Psychological frameworks / Kristina Henry
    Role-related frameworks / Rose Utley
    Economic frameworks / Kristina Henry
    Community and population health frameworks / Lucretia Smith
    Organizational systems frameworks / Kristina Henry
    Leadership frameworks for organizational systems / Kristina Henry
    Frameworks for evaluation / Rose Utley
    Sociocultural framework / Kristina Henry
    Application of frameworks to the nurse educator role / Rose Utley
    Application of frameworks to the clinician role / Maria Kenneally, Rose Utley
    Application of frameworks to leadership roles in nursing / Kristina Henry
    Application of frameworks to the nurse researcher role / Lucretia Smith.
    Digital Access R2Library 2018
    Limited to 1 simultaneous user
  • Article
    Acocella G.
    Clin Pharmacokinet. 1978 Mar-Apr;3(2):108-27.
    After oral administration on an empty stomach, the absorption of rifampicin (rifampin) is rapid and practically complete. With a single 600mg dose, peak serum concentration of the order of 10microgram/ml generally occur 2 hours after administration. The half-life of rifampicin for this dose level is of the order of 2.5 hours. The amount of rifampicin extracted by the liver during its first passage through the hepatoportal system and transferred to bile is relevance for the time course of distribution of the antibiotic in the blood compartment. With dose of the order of 300 to 450mg, the excretory capacity of the liver for the antibiotic is saturated. As a consequence, increasing the dose of antibiotic results in a more than proportional increase in serum concentrations. On repeated administration, and most likely as a consequence of self-induced (autoinduction) metabolism, the rate of disappearance of rifampicin from the blood compartment increases in the early phase of treatment, the phenomenon affecting mainly the levels following the peak, with a consequent reduction in half-life. Approximately 80% of rifampicin is transported in blood bound to plasma proteins, mainly albumin. Rifampicin is well distributed, although to a different degree, in the various tissues of the human body. Probably in the hepatocyte, rifampicin undergoes a process of desacetylation. The metabolic derivative, desacetylrifampicin, is more polar than the parent compound, and microbiologically active. This metabolite accounts for the majority of the antibacterial activity in the bile Rifampicin is almost equally excreted in the bile and urine, the recovery in the 2 fluids being of the same order of magnitude. Administration of rifampicin to newborn infants and children is followed by blood levels generally lower than those found in adults for the same dose levels. In patients with impaired liver and kidney function the elimination of the antibiotic from the blood compartment is slower than in normal subjects. Rifampicin has been found to compete with bilirubin and other cholefil substances for biliary excretion, giving rise to transient and reversible increased bilirubin and BSP retention values. A kinetic model study on the transfer constants between various body compartments has indicated that rifampicin is rapidly absorbed from the intestine and that the absorption rate increases with time. Rifampicin as such is transferred into urine at a rate 3 times higher than the rate of transfer into bile. Desacetylrifampicin, the more polar metabolic derivative of rifampicin, behaves in the opposite way since its rate of transfer into bile is 4 times higher than that into urine. The rate of biotransformation of rifampicin into desacetylrifampicin is of the same order of magnitude as than of biotransformation of the latter into a further metabolic derivative, which could be a glucuronide conjugate...
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