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  • Book
    Brahm H. Segal, editor.
    Summary: This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in the field and future directions of research. This book begins with an overview of the normally functioning immune system followed by a detailed discussion of the major primary immunodeficiencies. Specific chapters are dedicated to providing practical knowledge in the prevention and treatment of infections in specific immunocompromised patients, including those with cancer, transplant recipients, HIV infection, and autoimmune disorders. Emphasis is placed on diagnostic evaluation, antimicrobial selection that includes consideration of the threat of antimicrobial-resistant pathogens, and immunotherapy tailored to specific patients. Finally, dedicated chapters on stem cell transplantation for patients with primary immunodeficiencies, adoptive cellular immunotherapy, and gene therapy will provide readers with insight into these rapidly evolving and cutting edge therapies. Management of Infections in the Immunocompromised Host is a valuable resource for infectious diseases specialists, immunologists, oncologists, hematologists, general physicians, students, researchers, and all other working with immunocompromised patients.
    Digital Access Springer 2018
  • Article
    Branconnier RJ, Cole JO.
    J Gerontol. 1978 Mar;33(2):217-23.
    A method for the determination of drug efficacy in geriatric psychopharmacology is presented. Sixty patients with mild senile organic brain syndrome were evaluated by a battery of neuropsychological tests. Subsequently these patients were randomly assigned to either drug or placebo treatment for 90 days. One group received 300 mg per day of Naftidrofuryl (Praxilene) while the other received identical placebo. Upon retest, the data indicated that Naftidrofuryl produced significant improvements in reaction time, short-term memory, and iconic memory. Ten neuropsychological test scores as well as two POMS mood factors were incorporated into an Impairment Index. This index was drug sensitive and proved to be symptom independent.
    Digital Access Access Options