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  Part 2 MRCOG : single best answer questions

  Andrew Sizer, Chandrika Balachander, Nibedan Biswas, Richard Foon, Anthony Griffiths, Sheena Hodgett, Banchita Sahu, Martyn Underwood.

  Contents:
  Questions. IT, Governance and Research
  Core Surgical Skills
  Postoperative Care
  Surgical Procedures
  Antenatal Care
  Maternal Medicine
  Management of Labour
  Management of Delivery
  Postnatal Care
  Gynaecological Problems
  Subfertility
  Sexual and Reproductive Health
  Early Pregnancy Problems
  Gynaecological Oncology
  Urogynaecology and Pelvic Floor Problems
  Explanations. IT, Governance and Research
  Core Surgical Skills
  Postoperative Care
  Surgical Procedures
  Antenatal Care
  Maternal Medicine
  Management of Labour
  Management of Delivery
  Postnatal Care
  Gynaecological Problems
  Subfertility
  Sexual and Reproductive Health
  Early Pregnancy Problems
  Gynaecological Oncology
  Urogynaecology and Pelvic Floor Problems .

  Digital Access Wiley 2016
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• Article

  In vivo immune response suppression by the supernatant from concanavalin A-activated spleen cells.

  Reinertsen JL, Steinberg AD.

  J Immunol. 1977 Jul;119(1):217-22.

  Supernatants from concanavalin A- (Con A) activated murine spleen cells have been shown to suppress the in vitro plaque-forming cell (PFC) response to sheep red blood cells (SRBC). The present study examined the effect of such Con A-activated spleen cell supernatants (herein termed CONS) on the in vivo immune response to SRBC in C57BL/6, BALB/c and CDF1 mice. CONS derived from BALB/c spleen cells suppressed direct PFC 4 and 8 days after immunization with 2 X 10(8) SRBC. CONS also suppressed indirect PFC 8 days after immunization, as well as serum hemagglutinins to SRBC. The PFC response of C57BL/6 (H-2b) mice was suppressed as much as that of BALB/c (H-2d) by CONS derived from BALB/c mice, indicating a lack of H-2 specificity of the CONS. In addition to suppression of the antibody response to SRBC, in vivo CONS administration resulted in reduction in spleen cell number. This reduction was not sufficient to explain the decreased PFC response. When the CONS was separated into less than 10,000 m.w. and greater than or equal to 10,000 m.w. fractions, the immunosuppressive activity was found in the less than 10,000 m.w. fraction. This observation suggests that intact interferon, SIRS, and MIF were not responsible for the results obtained.

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  PubMed