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  • Book
    [editors], Vincent T. DeVita, Jr., MD, Amy & Joseph Perella, Professor of Medicine, ... Show More Yale Comprehensive Cancer Center and Smilow Cancer Hospital at Yale-New Haven Professor of Epidemiology and Public Health, Yale University, School of Public Health, New Haven, Conneticut, Theodore S. Lawrence, MD, PhD, Isadore Lampe Professor and Chair, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, Steven A. Rosenberg, MD, PhD, Chief, Surgery Branch, National Cancer Institute, National Institutes of Health, Professor of Surgery, Uniformed Services, University of the Health Sciences, School of Medicine, Bethesda, Maryland, Professor of Surgery, George Washington University, School of Medicine, Washington, DC.
    Contents:
    Part I: Principles of oncology. The cancer genome
    Hallmarks of cancer: an organizing principle for cancer medicine
    Molecular methods in cancer
    Part II: Etiology and epidemiology of cancer. Tobacco
    Oncogenic viruses
    Inflammation
    Chemical factors
    Physical factors
    Dietary factors
    Obesity and physical activity
    Section 2: Epidemiology of cancer. Epidemiologic methods
    Trends in United States cancer mortality
    Part III: Cancer therapeutics. Essentials of radiation therapy
    Cancer immunotherapy
    Pharmacokinetics and pharmacodynamics of anticancer drugs
    Pharmacogenomics
    Alkylating agents
    Platinum analogs
    Antimetabolites
    Topoisomerase interactive agents
    Antimicrotubule agents
    Kinase inhibitors as anticancer drugs
    Histone deacetylase inhibitors and demethylating agents
    Proteasome inhibitors
    Poly (ADP-ribose) polymerase inhibitors
    Miscellaneous chemotherapeutic agents
    Hormonal agents
    Antiangiogenesis agents
    Monoclonal antibodies
    Assessment of clinical response
    Part IV: Cancer prevention and screening. Tobacco use and the cancer patient
    Role of surgery in cancer prevention
    Cancer risk-reducing agents
    Cancer screening
    Genetic counseling
    Part V: Cancer of the skin. Cancer of the skin
    Molecular biology of cutaneous melanoma
    Cutaneous melanoma
    Genetic testing in skin cancer.
    Digital Access Ovid 2016
  • Article
    Bossinger J, Cooper TG.
    J Bacteriol. 1977 Jul;131(1):163-73.
    Arginase, the enzyme responsible for arginine degradation in Saccharomyces cerevisiae, is an inducible protein whose inhibition of ornithine carbamoyl-transferase has been studied extensively. Mutant strains defective in the normal regulation of arginase production have also been isolated. However, in spite of these studies, the macromolecular biosynthetic events involved in production of arginase remain obscure. We have, therefore, studied the requirements of arginase induction. We observed that: (i) 4 min elapsed between the addition of inducer (homoarginine) and the appearance of arginase activity at 30 degrees C; (ii) induction required ribonucleic acid synthesis and a functional rna1 gene product; and (iii) production of arginase-specific synthetic capacity occurred in the absence of protein synthesis but could be expressed only when protein synthesis was not inhibited. Termination of induction by inducer removal, addition of the ribonucleic acid synthesis inhibitor lomofungin, or resuspension of a culture of organisms containing temperature-sensitive rna1 gene products in a medium at 35 degrees C resulted in loss of ability for continued arginase synthesis with half-lives of 5.5, 3.8, and 4.5 min, respectively. These and other recently published data suggest that a variety of inducible or repressible proteins responding rapidly to the environment may be derived from labile synthetic capacities, whereas constitutively produced proteins needed continuously throughout the cell cycle may be derived from synthetic capacities that are significantly more stable.
    Digital Access Access Options