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  • Book
    Charles R. Scoggins, Chandrajit P. Raut, John T. Mullen, editors.
    Contents:
    Etiology/Epidemiology
    Pathology
    Molecular Genetics of GIST
    Pediatric GIST/Inheritable Disease
    Natural History
    Radiographic Imaging
    Endoscopic Evaluation
    Prognostic Factors for Localized Disease
    Management of Localized GIST: Non-Surgical Approaches-Surveillance and Endoscopic Resection
    Surgery for Localized GIST
    Minimally Invasive Surgery for GIST
    Neoadjuvant Rx and Surgical Consolidation
    Imatinib
    Management of Locally Advanced GIST
    Prognostic Factors for Advanced GIST
    Concepts of Targeted Therapy Management, Dose Escalation, Tailoring Therapy Based on Specific Mutations, Second Line Therapy
    Surgical Debulking of Metastatic GIST
    Liver Resection/Ablation of Metastatic GIST
    Palliative Care.
    Digital Access Springer 2016
  • Article
    Bliznakov EG.
    Biomedicine. 1977 Apr;26(2):73-6.
    Our experimental studies and extensive literature survey established that the overall response of an experimentally modified host defense system is strongly dose-dependent, irrespective of either the modifying agent or the test model system. If a sufficiently broad dose range is used, an irregular, nonlinear, nonmonotonic response curve is formed, generally W- or M-shaped, depending on the parameters selected for the representation, with two peaks of relative maximal effect. Accordingly, a modifying agent may exhibit, in some cases, dual effect--stimulation and depression, each at different dose levels. This typical response is defined as characteristic of the entire host defense system and therefore implies a biologically integrated system. The described dose-response relationship mandates the use of multiple doses in evaluation experiments, to establish efficacy and especially to design optimal dose schedules for experimental and clinical application of any agent modifying the host defense system activity.
    Digital Access Access Options