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  • Book
    René P. Michel, Gerald J. Berry, editors.
    Contents:
    1. Introduction
    2. Immunobiology and Immunopharmacology of Transplantation
    3. Pathology of Cardiac Transplantation
    4. Pathology of Hepatic Transplantation
    5. Pathology of Pancreatic Transplantation
    6. Pathology of Renal Transplantation
    7. Pathology of Pulmonary Transplantation
    8. Pathology of Intestinal Transplantation
    9. Pathology of Bone Marrow/Hematopoietic Stem Cell Transplantation
    10. Malignancies Post-Transplantation
    11. The Future of Transplantation Pathology.
    Digital Access Springer 2016
  • Article
    Ramey WG, Hashim GA, Pierce JC, Fitzpatrick HF.
    Surgery. 1977 Jun;81(6):640-5.
    The kinetics of circulating antigen sensitive T-cells were studied in Hartley strain guinea pig recipients of Shorthair strain first- and second-set skin allografts. Peripheral blood donor antigen sensitive T-cells (AST) were quantitated by the antigen-stimulated active rosette-forming T-cell (AgARFC) assay by incubating lymphocytes in the presence and in the absence of soluble transplantation antigens. The number of circulating AST/cu mm rose to maximum levels (1,165 +/- 272 SEM) by day 3 and fell sharply before first-set graft rejection (453 +/- 117 SEM) on day 7 after transplant. In contrast, there were no detectable antigen-sensitive cells when lymphocytes from both recipient and control guinea pigs were stimulated with soluble recipient-strain antigen. Significant numbers (212 +/- 159 SEM) of circulating AST remained through day 68 after first-set grafts. Following placement of sencon-set allografts on day 73, the AST disappeared from the circulation for 2.5 days and then rose to peak levels (825 +/- 167 SEM) in circulating AST (579 +/- 327 SEM) preceded rejection of second-set skin allografts. When control guinea pigs were immunized with a single dose of soluble donor antigens, a progressive increase in circulating AST (579 +/- 327 SEM) was found through day 17 after sensitization without the fall associated with graft rejection. The antigen-stimulated, rosette-forming T-cell assay may prove useful in the detection of cellular presensitization and in the monitoring of graft rejection in clinical transplantation.
    Digital Access Access Options