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  • Book
    Matthew Helbert.
    Contents:
    1. Introduction to the immune system
    2. Basic concepts and components of the immune system
    3. Introduction to the antigen recognition
    4. Antigens and antibody structure
    5. Antibody-antigen interaction
    6. Antibody diversity
    7. The T-cell receptor
    8. Major histocompatibility complex
    9. Review of antigen recognition
    10. Antigen processing and presentation
    11. Lymphocyte activation
    12. Hematopoiesis
    13. Organs and tissues of the immune system
    14. B-cell development
    15. T-cell development
    16. T-cell interactions and T=cell help
    17. Immunologic memory and homeostasis
    18. Regulation of the immune system
    19. Brief review of immune physiology
    20. Constitutive defense including complement
    21. Phagocytes
    22. Killing in the immune system
    23. Inflammation
    24. Cytokines in the immune system
    25. Infections and vaccines
    26. Hypersensitivity reactions
    27. Immediate hypersensitivity (Type I): allergy
    28. How autoimmune disease develops
    29. Antibody-mediated hypersensitivity (Type II)
    30. Immune complex disease (Type III hypersensitivity )
    31. Delayed hypersensitivity (Type IV) and review of hypersensitivity reactions
    32. Primary immunodeficiency
    33. Primary immunodeficiency
    33. Secondary immunodeficiency
    34. Transplantation
    35. Tumor immunology
    36. Biopharmaceuticals.
    Digital Access ClinicalKey 2017
  • Article
    Axelsson CK, Christiansen LV, Johansen A, Poulsen PE.
    Scand J Rheumatol. 1977;6(1):23-7.
    A comparative study has been made of the effects of tolfenamic acid (Clotam) and acetylsalicyclic acid on the gastric mucosa in 10 healthy volunteers. The effects were evaluated by means of gastroscopy, photography of the gastric mucosa, and multiple biopsies. The schedule was for a randomized, double-blind crossover trial involving two drug-administered periods of one week's duration separated by an interval of at least 3 weeks. On each day of the drug-administration weeks either tolfenamic acid 600 mg or acetylsalicyclic acid 3 g was administered as three divided doses, taken with meals. Gastroscopy was performed prior to and after each week of drug administration. Subjective side effects were recorded during the therapy periods; haematemesis occurred in 2 volunteers taking acetylsalicyclic acid. The absence of gastritis in each subject during treatment with tolfenamic acid was confirmed both gastroscopically and histologically. In contrast, 6 out of 10 volunteers developed mild superficial acute gastritis after ingestion of acetylsalicyclic acid. The difference in effect between the two treatments on the gastric mucosa was statistically significant(p less than 0.05). The findings of this study are comparable to those of other studies and it is concluded that tolfenamic acid, in the relatively high dosage employed in this trial, is free from any irritant effect on the gastric mucosa.
    Digital Access Access Options