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- ArticleBoucher C, Bergeron B, De Bertalmio MB, Dénarié J.J Gen Microbiol. 1977 Jan;98(1):253-63.Phage Mu-1 and a thermoinducible derivative, Mu-1 cts 62 were inserted into the broad host range R factor RP4. These hybrid plasmids were transferred by conjugation to a phytopathogenic bacterium Pseudomonas solanacearum GMI 1000 and a legume-root nodule bacterium Rhizobium meliloti 2011. The Mu genome is transcribed and tranlated in these new hosts: P. solanacearum (RP4:Mu cts) cultures have a spontaneous production of about 5 X 10(5) plaque-forming units ml-1 which is similar to the frequency of spontaneous Mu production in E. coli; the Mu production of R. meliloti is lower (about 10(2) plaque-forming units ml-1).
- BookVasilios Fragoulakis, Christina Mitropoulou, Marc S. Williams, George P. Patrinos.Contents:
Economic evaluation in health care: evidence-based medicine and evidence-based health economics
Genomic medicine today: an introduction for health economists
Economic evaluation and genomic medicine: what can they learn from each other?
Introduction to the technical issues of economic evaluation
Advanced methodological aspects in the economic evaluation
Economic evaluation in the genomic era: some examples from the field
Special requirements for economic evaluation and health technology assessment in genomic medicine
A new methodological approach for cost-effectiveness analysis in genomic medicine
Conclusions and future perspectives.Digital Access ScienceDirect 2015