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  • Book
    Andrea Poretti, Thierry A.G.M. Huisman, editors.
    Summary: This book discusses the key features of normal, age-dependent neonatal head and spine ultrasonography and the application of this modality to common and rare neonatal neurologic disorders. Ultrasonography is an incredibly versatile bedside imaging tool in detecting brain and spine abnormalities in neonates, monitoring the course of these lesions, and evaluating the maturation of the neonatal brain and spine. Organized to correspond to daily bedside practice, it presents a symptom-based approach and classifies neonatal neurologic disorders at presentation. For each disorder, clinical cases are presented that explore the differential diagnoses and are accompanied by high-quality ultrasound images that depict the abnormal findings. Topics include seizures, encephalopathy, hemiparesis, apnea, microcephaly, and neonatal spine abnormalities. Neonatal Head and Spine Ultrasonography is a succinct guide to this imaging modality and is a valuable resource for pediatric radiologists, neuroradiologists, neonatologists, and pediatricians.

    Contents:
    Introduction
    Technique
    Normal Head Ultrasound in the Preterm and Term Newborn
    Seizures Encephalopathy
    Muscular Hypotonia
    Hemiplegia
    Apnea
    Microcephaly
    Macrocephaly
    Dysmorphic Facial Features
    Facial Skin Abnormalities.
    Digital Access Springer 2016
  • Article
    Kraehenbuhl JP, Racine L, Jamieson JD.
    J Cell Biol. 1977 Feb;72(2):406-23.
    The bovine exocrine pancreatic cell produces a variety of enzymes and proenzymes for export. Biochemical studies by Greene L.J., C.H. Hirs, and G.E. Palade (J. Biol. Chem. 1963. 238:2054) have shown that the mass proportions of several of these proteins in resting pancreatic juice and zymogen granule fractions are identical. In this study we have used immunocytochemical techniques at the electron microscope level to determine whether regional differences exist in the bovine gland with regard to production of individual secretory proteins and whether specialization of product handling occurs at the subcellular level. The technique used is a modification of one previously reported (McLean, J.D., and S.J. Singer. 1970. Proc. Natl. Acad. Sci U.S.A. 69:1771) in which immunocytochemical reagents are applied to thin sections of bovine serum albumin-imbedded tissue and zymogen granule fractions. A double antibody technique was used in which the first step consisted of rabbit F(ab')2 antibovine secretory protein and the detection step consisted of sheep (F(ab')2 antirabbit F(ab')2 conjugated to ferritin. The results showed that all exocrine cells in the gland, and all zymogen granules and Golgi cisternae in each cell, were qualitatively alike with regard to their content of secretory proteins examined (trypsinogen, chymotrypsinogen A, carboxypeptidase A, RNase, and DNase). The data suggest that these secretory proteins are transported through the cisternae of the Golgi complex where they are intermixed before copackaging in zymogen granules; passage through the Golgi complex is apparently obligatory for these (and likely all) secretory proteins, and is independent of extent of glycosylation, e.g., trypsinogen, a nonglycoprotein vs. DNase, a glycoprotein.
    Digital Access Access Options