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  • Book
    Nima Rezaei, editor.
    Contents:
    Specific Organ Tumors: General Considerations On Immunotherapy
    Vaccination Of Human Solid Tumors: Recent Progress In The Clinical Setting
    Immunotherapy For Pediatric Solid Tumors
    Immunopathology Of Hematological Cancers And Immunotherapy Of Leukemia And Multiple Myeloma
    Immunopathology Of Lymphoma And Immunotherapy Of Hodgkin's Disease And Non-Hodgkin's Lymphoma
    Cancer-Testis Antigens As Targets For The Immunotherapy Of Hematological Malignancies
    Tumor Immunology And Immunotherapy Of Gastrointestinal Tract Cancers
    Immunology And Immunotherapy Of Colorectal Cancer
    Immunopathology Of Hepatobiliary Tumors And Immunotherapy Of Liver Cancers
    Immunology And Immunotherapy Of Pancreatic Tumors
    Immunology Of Cutaneous Tumors And Immunotherapy For Melanoma
    Immunopathology Of Head And Neck Tumors And Immunotherapy Of Squamous Cell Carcinoma
    Immunopathology And Immunotherapy Of Oral Cancers
    Immunopathology Of Bone And Connective Tissue Cancers And Immunotherapy Of Sarcomas
    Immunopathology Of Central Nervous System Cancers And Immunotherapy Of Brain Tumors
    Immunology And Immunotherapy Of Pulmonary Tumors
    Immunopathology Of Urinary System Cancers And Immunotherapy Of Renal And Bladder Cancers
    Immunopathology Of Cancers Of Male And Female Genitalia Organs And Immunotherapy Of Cervical And Prostate Cancer
    Immunology And Immunotherapy Of Ovarian Cancer
    Revisiting Immunology For Breast Cancer
    Immunology And Immunotherapy Of Graft Versus Host Disease.
    Digital Access Springer 2015
  • Article
    Scadding GK, Thomas HC, Havard CW.
    Clin Exp Immunol. 1979 May;36(2):205-13.
    Thymus-derived (T) lymphocytes in the peripheral blood and cellular immune function have been studied in ten patients with myasthenia gravis and in fifteen different myasthenic patients more than 10 years after thymectomy. The results were compared with those of a normal control population. The non-thymectomized myasthenic patients had normal T lymphocyte concentrations measured by rosetting with native sheep red cells. These patients also showed normal sensitization and recall of delayed hypersensitivity, phytohaemagglutinin (PHA) induced lymphocyte transformation and antibody-assisted (K cell) cytotoxicity; however, PHA-induced cytotoxicity was markedly reduced (P less than 0.001). The thymectomized group exhibited a lower mean percentage and absolute number of E-rosette-forming cells, which returned toward normal after in vitro treatment with thymosin. PHA-induced lymphocyte cytotoxicity, however, was normal in the patients who had undergone thymectomy, as were lymphocyte transformation, antibody-assisted cytotoxicity and sensitization to dinitrochlorobenzene (DNCB); there was a decrease in recall of established delayed hypersensitivity. Adult thymectomy in man, therefore, produces a partial and dissociated decrease in T cell responses and it is unlikely that the beneficial effect of this operation in myasthenia gravis is related to immunosuppression.
    Digital Access Access Options