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• Book

  Dental management of the medically compromised patient. 8th ed.

  James W. Little [and others].

  Contents:
  Patient evaluation and risk assessment
  Cardiovascular disease
  Pulmonary disease
  Gastrointestinal disease
  Genitourinary disease
  Endocrine and metabolic disease
  Immunologic disease
  Hematologic and oncologic disease
  Neurologic, behavioral, and psychiatric disorders.

  Digital Access ClinicalKey 2013
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• Article

  The anti-inflammatory profile of dapsone in animal models of inflammation.

  Lewis AJ, Gemmell DK, Stimson WH.

  Agents Actions. 1978 Dec;8(6):578-86.

  Dapsone has been shown to possess anti-inflammatory activity in a variety of animal models. It possesses oral anti-oedema activity especially pronounced in novel models of acute inflammation, viz. anti-IgG and reversed passive Arthus oedemas. However, it is not very active in the guinea pig u.v. erythema model. It is effective in chronic models such as adjuvant arthritis and the cotton pellet granuloma although multiple administration may also produce cyanosis. Antipyretic and analgesic effects for dapsone have been demonstrated and are similar to those produced by phenylbutazone. It inhibits zymosan-induced beta-glucuronidase release from cultured macrophages and also the activity of this enzyme. Dapsone does not appear to be ulcerogenic in the rat.

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  PubMed