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  • Book
    Edward S Friedman, Ian M Anderson ; with contributions from Danilo Arnone, Timothey Denko.
    Summary: Depression is a common mood disorder that affects approximately 10% of the global population at some point in their lives and can cause serious psychological, physical, and cognitive distress. Additionally, patients with depression are at a greater risk for cardiovascular disease, stroke, functional impairment, disability and all-cause mortality. Aside from the impact on the individual, this condition presents a very real economic burden, as depression is the most predominant mental health problem among working-age patients and the leading cause of lost work productivity. Despite advances in screening and treating depression in recent decades, a vast majority of patients with depression do not actively seek treatment and, of those that do, only a quarter have been found to receive adequate and effective interventions. Handbook of Depression, Second Edition is a concise review of assessment tools, available and emerging pharmacological and non-pharmacological treatment options, and consensus management guidelines that center on enhancing the clinician-patient relationship and improving patient quality of life. Cowritten by expert US- and UK-based authors, this handbook has an innovative global focus that consolidates current knowledge in a convenient, pocket-sized guide that is ideal for every day reference in a clinical setting.

    Contents:
    Chapter 1 Classification, causes and epidemiology
    Chapter 2 Depression in different types of patients
    Chapter 3 Disgnosis
    Chapter 4 Principles of therapy
    Chapter 5 Medications
    Chapter 6 Other treatments
    Chapter 7 Management of treatment nonresponse
    Chapter 8 Continuation andmaintenance treatment..
    Digital Access Springer 2014
  • Article
    Dimitrova A.
    Vet Med Nauki. 1978;15(2):72-6.
    Albino mice were immunized with a suspension of sheep erythrocytes. On the fifth day following treatment the animals were killed and B lymphocytes were isolated from their spleen tissue. Both the complement-fixation test and the immunofluorescence method were employed to specify the number of immunoglobulin receptors on the membrane surface, and disk electrophoresis was used to separate the protein fractions of the solubilizates from their membranes. Normal lymphocytes, obtained from unimmunized animals, were used as controls. It was established that: 1. The immunoglobulin receptors gradually decreased in number is the stimulated lymphocytes. On the fifth day of immunization their amount was 6.6 times lower than that in the normal lymphocytes. 2. The receptors in the normal lymphocytes proved diffusely scattered on the cell surface, while those in the stimulated lymphocytes were concentrated into clusters at one of the cell poles. The biologic nature of the observed changes is briefly discussed. It is concluded that the mature antibody-producing cell is not dependent on the antigen.
    Digital Access Access Options