BookIhor Gussak, Charles Antzelevitch (eds.).
Summary: The past two decades have witnessed an explosion of knowledge and radical changes in our understanding of the molecular, ionic, genetic, and pharmacologic basis of electrical diseases of the heart. Electrical diseases of the heart are heritable arrhythmogenic clinical entities that may share common clinical and genetic features, yet may be distinctly different in their genesis, prognosis, and management. Notably, both congenital and acquired electrical diseases of the heart are receiving increased recognition as a result of important advances in genetic analysis. In this second edition of Electrical Diseases of the Heart, the Editors' goal has been to embrace and highlight the explosion of knowledge that our field has witnessed since the publication of the first edition. The approach continues to be one of bridging basic and clinical science in an attempt to advance meaningfully our understanding of heart disease and identify the knowledge gaps that exist. This volume covers the basic foundations and primary electrical diseases and with the companion volume provides the latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities. Residents, fellows and physicians in cardiology and electrophysiology will gain valuable insight into the latest developments in the field of cardiac electrophysiology and clinical electrocardiology by reading this book, including expert review of the genetic and epidemiologic considerations, diagnostic and therapeutic modalities of the newly discovered clinical syndromes and electrocardiographic phenomena, and their correlation with the most recent advances in the basic science.
Contents:
Part I: Basic Fundamentals of Normal and Abnormal Cardiac Electrical Activity
Introduction to Part I: Basic Cardiac Electrophysiology - Promises Kept and Promises to Keep
Basic Physiology of Ion Channel Function
Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form
Anatomic and Histopathologic Characteristics of the Conductive Tissues of the Heart
Neural Regulation of the Heart in Health and Disease
Mechanisms of Cardiac Arrhythmia
Mechanisms of Cardiac Arrhythmia in Ventricular Arrhythmias
Mechanisms of Action of Antiarrhythmic Drugs in Atrial Fibrillation
Mechano-Electric Interactions and Their Role in Electrical Function of the Heart
Pathological Roles of the Cardiac Sodium Channel Late Current (Late I[Na])
Sodium Ion Channelopathies
L-Type Calcium Channel Disease
Nerve Sprouting, Defibrillation and Calcium Waves
K+ Channelopathies (I[Ks], I[Kr], and I[to])
Cardiac ATP-Sensitive Potassium Channels and Associated Channelopathies
Cardiac K[ATP] Channels in Health and Diseases
Ca2+ Release Channels (Ryanodine Receptors)
Caveolae and Arrhythmogenesis
Senescence and Arrhythmogenesis
Comparisons of Substrates Responsible for Atrial Versus Ventricular Fibrillation
Single Nucleotide Polymorphisms in Health and Cardiac Disease
Electrophysiological Remodeling in Heart Failure
Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy
Physiological and Other Biological Pacemakers
Cardiac Memory: From Electrical Curiosity to Clinical Diagnostic and Research Tool
Part II: Heritable Arrhythmogenic Channelopathies, Primary Electrical Diseases, and Sudden Cardiac Death
Introduction to Part Two: Celebrating the Challenge of Cardiac Arrhythmias
Congenital Long QT Syndrome
Brugada Syndrome: Clinical and Genetic Aspects
Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy
Early Repolarization Syndrome: Epidemiology, Genetics, and Risk Stratification
Catecholaminergic Polymorphic Ventricular Tachycardia
Andersen-Tawil and Timothy Syndromes
Short QT Syndrome
Progressive Cardiac Conduction Disease
Genetics of Atrial Fibrillation and Standstill
Idiopathic Ventricular Fibrillation.