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  • Book
    Cesare Gridelli, Riccardo A. Audisio, editors.
    Summary: This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older lung cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

    Contents:
    Part I: Background and Epidemiology
    Basic Science of Lung Cancer in Older Patients
    Clinical Epidemiology and the Impact of Comorbidity on Treatment and Outcome
    Part II: Special Considerations in the Management of Older Patients
    Physiological Assessment and Cardiopulmonary Exercise Testing
    A Practical Mini-Guide to Geriatric Assessment
    Impact of the Physiological Effects of Aging on the Pharmacokinetics and Pharmacodynamics of Systemic Lung Cancer Treatment
    Drug Interactions and Polypharmacy
    Part III: Diagnostics
    Selection of Appropriate Surgery for Early Lung Cancer
    Part IV: Non Small-Cell Lung Cancer: Treatment of Early Stages
    Surgery: Indications and Issues
    Is There a Role for Postoperative Radiotherapy in Elderly Patients with Early-Stage Non-small Cell Lung Cancer?
    Is There a Role for Neoadjuvant Chemotherapy in Older Patients?
    Curative Radiotherapy in Patients Inoperable for Medical Reasons
    Part V: Non Small-Cell Lung Cancer: Treatment of Locally Advanced Disease
    Adjuvant Chemotherapy: Feasibility in the Elderly and Patient Selection
    Locally Advanced Non-Small Cell Lung Cancer in the Elderly: What Combination of Therapy Is Best?
    Part VI: Non Small-Cell Lung Cancer: Treatment of Advanced Disease
    First-Line Treatment and the New Paradigm of Histology-Based Treatment
    Treatment of Frail Patients and Octogenarians with Advanced NSCLC
    Are Second- and Third-Line Treatments in the Elderly Feasible?
    Part VII: Small-Cell Lung Cancer: Therapeutics
    Treatment of Limited-Stage Disease in Older Patients: The Role of Thoracic Radiotherapy and Prophylactic Cranial Irradiation
    Chemotherapy in the Elderly: Standard Chemotherapy or Specific Regimens?.
    Digital Access Springer 2013
  • Article
    Bernard CC, Mitchell GF, Leydon J, Bargerbos A.
    Int Arch Allergy Appl Immunol. 1978;56(3):256-63.
    Experimental autoimmune orchitis (EAO) was induced in inbred strains of mice by injection of mouse testis homogenate (MTH) in Freund's complete adjuvant with pertussis vaccine. Although all mice injected with MTH and adjuvants developed signs of EAO, there were marked strain variations in susceptibility to EAO suggesting that genetic factors may be involved in the response to antigen or to adjuvants. Studies in hypothymic BALB/c. nu/nu mice indicated that a source of T cell was required for induction of EAO. Thus BALB/c. nu/nu mice were not able to develop EAO, despite adequate orchitogenic challenge; reconstitution of nu/nu mice with syngeneic thymocytes completely restored the capacity of such mice to develop orchitis. Transfer of EAO was effected in nu/nu mice with lymphoid cells from appropriately immunized donors but not with immune serum. However, both T cells and antibodies may be necessary in the effector stages of the disease since the capacity of lymphoid cells to transfer EAO was only partially inhibited by anti-Thy-1.2 treatment.
    Digital Access Access Options