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- ArticleBurney RG, DiFazio CA, Foster JA.Anesth Analg. 1978 Jul-Aug;57(4):478-80.Protein binding of lidocaine (2.5, 5, 10, and 20 microgram/ml in fresh plasma was studied from pH 5.6 to pH 9.8. Percent binding of lidocaine was inversely related to hydrogen-ion and lidocaine concentrations.