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  • Book
    Russell A. Poldrack, Jeanette A. Mumford, Thomas E. Nichols.
    Contents:
    Introduction
    Image processing basics
    Preprocessing fMRI data
    Spatial normalization
    Statistical modeling: single subject analysis
    Statistical modeling: group analysis
    Statistical inference on images
    Modeling brain connectivity
    Multivoxel pattern analysis and machine learning
    Visualizing, localizing, and reporting fMRI data
    Review of general linear model
    Data organization and management
    Image formats.
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2011
    RC386.6.B7 P65 2011
    1
  • Article
    Stoller RG, Hande KR, Jacobs SA, Rosenberg SA, Chabner BA.
    N Engl J Med. 1977 Sep 22;297(12):630-4.
    To correlate the pharmacokinetics and toxicity of methotrexate, we measured the drug's clearance from plasma after 395 high-dose, six-hour infusions given to 78 patients. After 375 infusions, 48 hour methotrexate levels fell within 2 standard deviations of the mean for nontoxic infusions, and myelosuppression did not occur. Methotrexate concentrations exceeded the range for nontoxic patients (mean +/- 2 standard deviations) after 20 infusions. Serious myelosuppression occurred after six of these 20 infusions, including five of 12 infusions associated with 48-hour drug concentrations above 9 X 10(-7) M. In seven patients with 48-hour concentrations above 9 X 10(-7) M, the absence of toxicity could be attributed to subsequent rapid clearance of the drug; four of these patients also received large doses of supplemental leucovorin (50 to 100 mg per square meter every six hours). Determination of methotrexate concentration in plasma thus identified patients at high risk of toxicity, a group that may benefit from supplemental leucovorin rescue.
    Digital Access Access Options