BookStefan Fruehauf, W. Jens Zeller, Gary Calandra, editors.
Contents:
Part 1. Basic Science and Experimental Studies on Stem Cell Mobilization
Preclinical Experience with AMD3100 for Mobilization of Hematopoietic Stem and Progenitor Cells
Molecular Pharmacology of CXCR4 Inhibition
Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors
Should We Stay or Should We Go Now?
Cell Adhesion and Mobilization Pathways of Hematopoietic Cells
Role of the CXCR4/CXCL12 Axis in Hematopoietic Stem Cell Trafficking
Part 2. Clinical Studies on Stem Cell Mobilization
Front matter
Early Studies of AMD3100/Plerixafor in Healthy Volunteers
The Current Role of Plerixafor in Stem Cell Mobilization for Hematopoietic Stem Cell Transplantation
Experience with Apheresis Procedures After Plerixafor Mobilisation
Influence of Different Stem Cell Mobilization Strategies on Graft Composition and Outcome of Autologous or Allogeneic Transplantation
Relevance and Clinical Implications of Tumor Cell Mobilization in Autologous Transplantation of Multiple Myeloma and Non-Hodgkin's Lymphoma
Plerixafor: Data from the Compassionate Use Program
Stem Cell Mobilization with Chemomobilization Plus Plerixafor in Hard-to-Mobilize Patients: The Experience at Kuopio University Hospital, Finland
Blood Stem Cell Mobilization in Solid Tumors: Experience with Plerixafor and Alternative Ways of Hematopoietic Stem Cell Mobilization
Mobilization with Chemotherapy + G-CSF + Plerixafor in Europe: The Italian Experience
Experience with Plerixafor in Poor Mobilizers
CXCR4 Antagonists
Part 3. CXCR4 Antagonists for Treatment of Leukemias and Solid Tumors
Front matter
Application of CXCR4 Inhibitors in Leukemia
CXCR4 Antagonists for the Treatment of CML
Targeting CXCR4 in Chronic Lymphocytic Leukemia: Preclinical Rationale and Early Clinical Experience
CXCR4-Blockade for Treatment of Breast Cancer
Molecular Imaging of CXCR4 Receptor Expression in Tumors
Part 4. Novel applications
Potential Use of CXCR4 Antagonists to Mobilize Endothelial and Mesenchymal Stem Cells
Strategies to Enhance Hematopoietic Stem Cell Engraftment Following Transplantation
Mobilization for Gene Therapy.