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  • Book
    Stefan Fruehauf, W. Jens Zeller, Gary Calandra, editors.
    Digital : Springer2012
    Part 1. Basic Science and Experimental Studies on Stem Cell Mobilization -- Preclinical Experience with AMD3100 for Mobilization of Hematopoietic Stem and Progenitor Cells -- Molecular Pharmacology of CXCR4 Inhibition -- Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors -- Should We Stay or Should We Go Now? -- Cell Adhesion and Mobilization Pathways of Hematopoietic Cells -- Role of the CXCR4/CXCL12 Axis in Hematopoietic Stem Cell Trafficking -- Part 2. Clinical Studies on Stem Cell Mobilization -- Front matter -- Early Studies of AMD3100/Plerixafor in Healthy Volunteers -- The Current Role of Plerixafor in Stem Cell Mobilization for Hematopoietic Stem Cell Transplantation -- Experience with Apheresis Procedures After Plerixafor Mobilisation -- Influence of Different Stem Cell Mobilization Strategies on Graft Composition and Outcome of Autologous or Allogeneic Transplantation -- Relevance and Clinical Implications of Tumor Cell Mobilization in Autologous Transplantation of Multiple Myeloma and Non-Hodgkin's Lymphoma -- Plerixafor: Data from the Compassionate Use Program -- Stem Cell Mobilization with Chemomobilization Plus Plerixafor in Hard-to-Mobilize Patients: The Experience at Kuopio University Hospital, Finland -- Blood Stem Cell Mobilization in Solid Tumors: Experience with Plerixafor and Alternative Ways of Hematopoietic Stem Cell Mobilization -- Mobilization with Chemotherapy + G-CSF + Plerixafor in Europe: The Italian Experience -- Experience with Plerixafor in Poor Mobilizers -- CXCR4 Antagonists -- Part 3. CXCR4 Antagonists for Treatment of Leukemias and Solid Tumors -- Front matter -- Application of CXCR4 Inhibitors in Leukemia -- CXCR4 Antagonists for the Treatment of CML -- Targeting CXCR4 in Chronic Lymphocytic Leukemia: Preclinical Rationale and Early Clinical Experience -- CXCR4-Blockade for Treatment of Breast Cancer -- Molecular Imaging of CXCR4 Receptor Expression in Tumors -- Part 4. Novel applications -- Potential Use of CXCR4 Antagonists to Mobilize Endothelial and Mesenchymal Stem Cells -- Strategies to Enhance Hematopoietic Stem Cell Engraftment Following Transplantation -- Mobilization for Gene Therapy.