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- ArticleMattsson W, Gynning I, Tropé C, Astedt B.Acta Radiol Ther Phys Biol. 1977 Apr;16(2):97-108.Combination chemotherapy (vincristine, adriamycin, cyclophosphamide, methotrexate with leucoverin rescue) in 32 patients with metastatic carcinoma of the breast resulted in an overall response rate of 81 per cent (9/32 complete remission, 17/32 partial remission). No serious side effects were noted. Karnofsky performance index improved in 24/26 responders.