Today's Hours: 12:00pm - 8:00pm
Lane Medical Library

Search

Filter Results

Did You Mean:

Search Results

Sort by
relevance
  • Book
    Margret Schuller, Theo P. Sloots, Gregory S. James, Catriona L Halliday, Ian W.J. Carter, editors.
    Contents:
    Part 1. PCR Fundamentals
    Part 2. Clinical Aspects and Diagnosis of Infectious Disease
    Part 3. PCR Protocols for Bacterial Pathogens
    Part 4. PCR Protocols for Viral Pathogens
    Part 5. PCR Protocols for Fungal and Parasitic Pathogens
    Part 6. Susceptibility Screening.
    Digital Access Springer 2010
  • Article
    Carson DD, Lennarz WJ.
    Proc Natl Acad Sci U S A. 1979 Nov;76(11):5709-13.
    Compactin, a potent inhibitor of polyisoprenoid biosynthesis, induces abnormal gastrulation during sea urchin development at concentrations that have no effect on earlier embryonic development or on macromolecular synthesis. Three lines of evidence suggest that the developmental lesion caused by compactin results from inhibition of dolichol biosynthesis and a concomitant inhibition in the biosynthesis of the oligosaccharide chains of N-linked glycoproteins. (i) Embryos cultured in the presence of compactin gastrulate normally when supplemented with dolichol alone, whereas supplementation with cholesterol or coenzyme Q or both does not prevent the compactin-induced developmental lesion. (ii) Exogenously supplemented [3H]dolichol is incorporated into a compound with the chromatographic properties of oligosaccharide-pyrophosphoryldolichol. (iii) Embryos cultured in the presence of compactin exhibit a decreased capacity to synthesize mannose-labeled glycolipids and N-linked glycoproteins. This decrease in synthesis is abolished if the embryos are cultured in the presence of dolichol along with compactin.
    Digital Access Access Options