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  • Book
    Meeta Goswami, S.R. Pandi-Perumal, Michael J. Thorpy, editors.
    Contents:
    Etiology
    Narcolepsy: genetic predisposition and pathophysiology
    Animal models of narcolepsy: development, findings and perspectives
    Neuroimaging of narcolepsy
    Clinical considerations
    Epidemiology of narcolepsy
    Narcolepsy in childhood
    Narcolepsy in the older adult
    Diurnal and nocturnal sleep in narcolepsy with cataplexy
    Hypnagogic hallucinations and sleep paralysis
    REM sleep behavior disorder in narcolepsy with cataplexy
    Narcolepsy and other comorbid medical illnesses
    Humor processing in human narcolepsy with cataplexy
    Dreams in patients with narcolepsy
    Psychoanalysis and narcolepsy
    Symptomatic narcolepsy or hypersomnia, with and without hypocretin (orexin) deficiency
    Hypersomnias other than narcolepsy: differential diagnosis
    Psychosocial considerations
    Psychosocial impact of narcolepsy in children and adolescents
    Quality of life and psychosocial issues in narcolepsy
    Narcolepsy, intimacy and sexuality
    Narcolepsy, driving and traffic safety
    Memory and cognition in narcolepsy
    Medico-legal aspects of disability in narcolepsy
    Narcolepsy and mental health
    Management
    Overview of management of narcolepsy
    Modes of action of drugs related to narcolepsy: pharmacology of wake-promoting compounds and anticataplectics
    Modafinil/Armodafinil in the treatment of narcolepsy
    Sodium oxybate in the treatment of narcolepsy
    Emerging treatments for narcolepsy
    Non-pharmacologic treatments of narcolepsy.
    Digital Access Springer 2010
  • Article
    Feramisco JR.
    Proc Natl Acad Sci U S A. 1979 Aug;76(8):3967-71.
    alpha-Actinin from chicken gizzard labeled with tetramethylrhodamine isothiocyanate has been incorporated into living fibroblast cells by microinjection. Fluorescent labeling of alpha-actinin was carried out such that the conjugated protein was functional in vitro as shown by its ability to bind to F-actin. Within 1-2 hr after injection, diffuse fluorescence was observed throughout the cytoplasm and only faint fluorescence was apparently associated with the stress fibers. During the ensuing 2-15 hr, however, most of the fluorescence was seen as periodicities along the stress fibers and as foci of the microfilament polygonal networks. This distribution of alpha-actinin in the living cells was strikingly similar to that found by indirect immunofluorescence localization of endogenous alpha-actinin in fixed samples of the same cell type. Control studies in which heat-treated (100 degrees C, 2 min) fluorescent alpha-actinin or tetramethylrhodamine isothiocyanate alone was injected into the cells indicated that the stress fiber and polygonal network labeling was specific for "native" fluorescently labeled alpha-actinin. These results suggest that the dynamic properties of proteins and structures in cultured mammalian cells can be studied with the use of microinjection and fluorescence microscopic techniques.
    Digital Access Access Options