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- ArticleBottomley WK, Perlin E, Ross GR.Oral Surg Oral Med Oral Pathol. 1977 Oct;44(4):527-34.The use of antineoplastic agents is rapidly increasing. A general classification of these drugs and their mechanisms of action is presented. Many of the drugs have an adverse effect on oral tissue, and the practicing dentist today must be well acquainted with these effects. A discussion of the features of these reactions and their management is presented.