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  • Journal
    Digital Access Nature v. 32-, 2003-
  • Book
    M.I. Tugan-Baranovskiĭ ; redakt͡sionnai͡a kollegii͡a, L.A. Bulochnikova ... [et al.].
    Print 1989
  • Article
    Cohen MV, Yipintsoi T, Malhotra A, Penpargkul S, Scheuer J.
    J Appl Physiol Respir Environ Exerc Physiol. 1978 Nov;45(5):797-805.
    To determine the effects of chronic exercise on the coronary collateral circulation of dogs with normal coronary arteries, 1-yr-old purebred beagles were divided into sedentary control and exercising groups. The latter were trained to run on a treadmill. A lower maximal heart rate during a standardized exercise test protocol after a 10- to 12-week training period and a higher gastrocnemius cytochrome oxidase activity in the runners attested to the presence of cardiovascular and skeletal muscle training effects. However, left ventricular weights, left ventricle/body weight ratios, myocardial myofibrillar and myosin ATPases, and hemodynamics were similar in sedentary and exercising dogs except for a significantly higher resting cardiac output in the runners. After occlusion of the left anterior descending coronary artery, both collateral conductance (retrograde flow/aortic pressure) and collateral flow measured with microspheres tended to be lower in the trained dogs, but differences were not significant. The endocardial/epicardial flow ratio in the ischemic area after coronary occlusion did not distinguish between exercisers and controls. Thus treadmill running in the dog with normal coronary arteries produced a training effect, but had no effect on coronary collateral vessels.
    Digital Access Access Options