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- ArticleBrun B, Clavert A, Warter S.C R Seances Soc Biol Fil. 1975;169(6):1596-9.Human semen in two chromosomal abnormalitie cases presents one important increase of small, large and double head spermatozoa. Findings of this type of abnormal sperm morphology must be include chromosome analysis in the subfertile couple investigations.