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  • Book
    Käfer, Hans.
    Print Access Request
    Location
    Version
    Call Number
    Items
    Stored offsite. Please request print.
    1941.
    M151 .K11 1941
    1
  • Article
    Adams WJ, Krueger DS.
    J Pharm Sci. 1979 Sep;68(9):1138-40.
    A specific and sensitive high-performance liquid chromatographic method has been developed for the rapid determination of intact glyburide in dog serum. With butylparaben as an internal standard, 1 ml of acid-buffered serum was extracted with toluene and an aliquot of the toluene was evaporated to dryness. The redissolved residue was chromatographed on a microparticulate reversed-phase column, and quantitation was achieved by monitoring the UV absorbance of the eluate at 228 nm. The response was linear, and the lower detection limit was approximately 20 ng/ml. Assay precision, as estimated by analyzing replicate samples of a laboratory standard, was better than 6% (CV). The utility of the analytical methodology for the determination of this highly potent sulfonylurea in pharmacokinetic studies in the dog was demonstrated.
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