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    edited by Hari Shanker Sharma, Aruna Sharma.
    Intro -- Progress in Brain Research -- Copyright -- Contributors -- Contents -- Acknowledgments -- Preface -- References -- Chapter 1: Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of ... -- 1. Introduction -- 1.1. Histaminergic system in the brain -- 1.2. Histaminergic receptors in the brain -- 1.3. Histamine in brain diseases -- 1.3.1. Cognitive dysfunction and Alzheimer's disease -- 1.3.2. Motor disorders and Parkinson's disease -- 1.3.3. Schizophrenia -- 1.3.4. Multiple sclerosis -- 1.3.5. Sleep disorders 1.3.6. Addictive disorders -- 2. Histaminergic system alterations in Parkinson's disease -- 2.1. Histamine concentration in PD -- 2.2. Histaminergic nerve fibers in PD -- 2.3. Histaminergic gene and receptors in PD -- 2.3.1. HMT and HDC gene expression are altered in PD brain -- 2.3.2. Histamine H3 and H4 receptor expression are altered in PD brain -- 3. Our own investigations on histamine modulation of Parkinson's disease -- 3.1. Methodological consideration -- 3.1.1. Animals -- 3.2. Animal model of PD -- 3.3. Modulation of histaminergic agents 3.3.1. Histamine H3 receptor inverse agonist BF2649 -- 3.3.2. Histamine H3 receptor antagonist and partial H4 receptor agonist clobenpropit -- 3.3.3. Anti-histamine mouse monoclonal antibody -- 3.3.4. TiO2 nanodelivery of pharmacological agents -- 3.4. Parameters measured -- 3.4.1. Physiological parameters -- 3.4.2. Physiological variables -- 3.4.3. Blood-brain barrier permeability -- 3.4.3.1. Albumin immunohistochemistry -- 3.4.4. Cerebral blood flow -- 3.4.5. Brain edema formation -- 3.5. Behavioral functions -- 3.5.1. Rota Rod treadmill -- 3.5.2. Immobility during forced swimming 4.1.2. Physiological variables in MPTP model of PD -- 4.1.2.1. Mean arterial blood pressure -- 4.1.2.2. Arterial pH -- 4.1.2.3. Arterial PaCO2 -- 4.1.2.4. Arterial PaO2 -- 4.1.2.5. Heart rate -- 4.1.2.6. Respiration rate -- 4.1.3. Behavioral parameters in MPTP model of PD -- 4.1.3.1. Rota-Rod performance -- 4.1.3.2. Forced swimming immobility -- 4.1.4. Biochemical parameters of MPTP model of PD -- 4.1.4.1. Tyrosine hydroxylase enzyme -- 4.1.4.2. Dopamine -- 4.1.4.3. DOPAC -- 4.1.5. Hallmarks of biomarkers in MPTP model of PD -- 4.1.5.1. ASNC -- 4.1.5.2. p-tau
    Digital Access  ScienceDirect 2021