Bookedited by Hari Shanker Sharma, Aruna Sharma.
Contents:
Intro
Progress in Brain Research
Copyright
Contributors
Contents
Acknowledgments
Preface
References
Chapter 1: Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of ...
1. Introduction
1.1. Histaminergic system in the brain
1.2. Histaminergic receptors in the brain
1.3. Histamine in brain diseases
1.3.1. Cognitive dysfunction and Alzheimer's disease
1.3.2. Motor disorders and Parkinson's disease
1.3.3. Schizophrenia
1.3.4. Multiple sclerosis
1.3.5. Sleep disorders 1.3.6. Addictive disorders
2. Histaminergic system alterations in Parkinson's disease
2.1. Histamine concentration in PD
2.2. Histaminergic nerve fibers in PD
2.3. Histaminergic gene and receptors in PD
2.3.1. HMT and HDC gene expression are altered in PD brain
2.3.2. Histamine H3 and H4 receptor expression are altered in PD brain
3. Our own investigations on histamine modulation of Parkinson's disease
3.1. Methodological consideration
3.1.1. Animals
3.2. Animal model of PD
3.3. Modulation of histaminergic agents 3.3.1. Histamine H3 receptor inverse agonist BF2649
3.3.2. Histamine H3 receptor antagonist and partial H4 receptor agonist clobenpropit
3.3.3. Anti-histamine mouse monoclonal antibody
3.3.4. TiO2 nanodelivery of pharmacological agents
3.4. Parameters measured
3.4.1. Physiological parameters
3.4.2. Physiological variables
3.4.3. Blood-brain barrier permeability
3.4.3.1. Albumin immunohistochemistry
3.4.4. Cerebral blood flow
3.4.5. Brain edema formation
3.5. Behavioral functions
3.5.1. Rota Rod treadmill
3.5.2. Immobility during forced swimming 4.1.2. Physiological variables in MPTP model of PD
4.1.2.1. Mean arterial blood pressure
4.1.2.2. Arterial pH
4.1.2.3. Arterial PaCO2
4.1.2.4. Arterial PaO2
4.1.2.5. Heart rate
4.1.2.6. Respiration rate
4.1.3. Behavioral parameters in MPTP model of PD
4.1.3.1. Rota-Rod performance
4.1.3.2. Forced swimming immobility
4.1.4. Biochemical parameters of MPTP model of PD
4.1.4.1. Tyrosine hydroxylase enzyme
4.1.4.2. Dopamine
4.1.4.3. DOPAC
4.1.5. Hallmarks of biomarkers in MPTP model of PD
4.1.5.1. ASNC
4.1.5.2. p-tau