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  • Book
    Euan Angus Ashley, M.D., Ph.D.
    Summary: "In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It's as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley's team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized"-- Provided by publisher.

    Contents:
    Preface
    Part I: The early genomes. Patient Zero
    Team of teams
    Once removed
    Genome illumination
    First family
    Buffalo buffalo buffalo
    Starting up, reaching out
    Part II: Disease detectives. Undiagnosed
    The luck of the Irish
    Next-day delivery
    Hoofbeats in Central Park
    Part III: Affairs of the heart. Whisky à go-go
    How many genomes are you?
    Shake, rattle, and roll
    River of the land of pine trees
    Songs in the key of life
    Part IV: Precisely accurate medicine. Superhumans
    Precision medicine
    Genome surgery
    The road ahead.
    Print Unavailable: Checked out Recall Item
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2021
    QH447 .A84 2021
    1
  • Journal
    Print Began with 1968; ceased with 2008.
  • Article
    Shmel'kov IuA, Zhevandrova VI, Drozdov SG.
    Vopr Virusol. 1978 May-Jun(3):332-6.
    The influence of vaccination with live poliomyelitis monovaccines on the formation of immunoglobulins in the blood serum and the buccal secrets was studied in infants under 1 year. There was a correlation between rises in the levels of serum immunoglobulins (Ig) of the A, G, and M classes and titers of neutralizing antibody to the three poliomyelitis virus types. The highest level of secretory IgA was observed after immunization with type I monovaccine. The level of secretory IgA correlated with the virus-neutralizing activity of the buccal cavity secretes for poliomyelitis virus types I, II, and III. After immunization with type II and III monovaccines there was an insignificant increase of the IgA content in the buccal cavity secretes. In contrast to poliovirus type I which was isolated from throat samples in 40% of the vaccinees, the other two types of poliomyelitis virus were not found in throat swabs. It is suggested that in the course of immunization with live poliovirus vaccine there are differences in the immunogenesis to poliovirus of different types.
    Digital Access Access Options