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  • Book
    [edited by] Richard A. Polin, Mark F. Ditmar.
    Contents:
    Adolescent medicine
    Behavior and development
    Pediatric cardiology
    Dermatology
    Emergency medicine
    Endocrinology
    Gastroenterology
    Genetics
    Hematology
    Infectious diseases
    Neonatology
    Nephrology
    Neurology
    Oncology
    Orthopedics
    Pulmonology
    Rheumatology.
    Digital Access ClinicalKey 2021
    Print Access Request
    Location
    Version
    Call Number
    Items
    Exam Review Books (shelved at Information Desk)
    2021
    RJ48.2 .P65 2021
    1
  • Article
    Davies PJ, Parry JM.
    Mol Gen Genet. 1978 Jun 14;162(2):183-90.
    Treatment of diploid yeast cultures with the amino acid analogue, para-fluorophenylalanine (PFPA), at concentrations which caused inhibition of growth, resulted in up to 5 fold increases in the frequency of mitotic gene conversion at two different heteroallelic loci. With haploid yeast cultures, growth in PFPA increased the rate of forward mutation to canavanine resistance by at least 2 fold. Growth of diploids in PFPA prior to exposure to the deaminating agent nitrous acid, the cross-linking agent mitomycin C, the alkylating chemical ethylmethanesulphonate (EMS) and UV light resulted in significant changes in the potency of these diverse mutagens to induce intragenic recombination. For all four mutagens, increased frequencies of gene convertants/viable cell were observed in those cultures which had been exposed to the amino acid analogue prior to mutagen treatment. In haploid WT yeast cells, amino acid analogue incorporation resulted in an enhanced frequency of UV induced forward mutation to canavanine resistance whilst in a DNA repair deficient rad 6 mutant this interaction between UV and PFPA was abolished. The results have been interpreted on the basis of incorporation of the analogue into enzymes involved with DNA replication with a consequent loss of fidelity of such enzymes and increased errors in base incorporation.
    Digital Access Access Options