BookCarolina Witchmichen Penteado Schmidt.
Summary: This unique book is the first on pediatric hematopoietic stem cell transplantation that is especially intended for pharmacists - in recognition of the fact that Pediatric Oncology Pharmacy is an area where more and more specific knowledge is required in daily practice, yet pharmacists who work in pediatric stem cell transplantation do not have a book addressing their specific needs. This pioneering book will likely become the new gold standard for practice, addressing subjects such as stem cells and their differentiation mechanisms; aspects of embryonic and non-embryonic stem cells; stem cell transplantation in pediatrics; stem cell sources and related technical choices; stem cell donors; scheduling transplantations; diseases and chemotherapy protocols that require stem cell transplantation; stem cell homing; engraftment and repopulation of stem cells in bone marrow; autologous stem cell transplantation in pediatrics; allogeneic stem cell transplantation in pediatrics; and indications for autologous and allogeneic pediatric stem cell transplantation. Further, it discusses pediatric graft-versus-host disease and the pharmacist; antibacterial and antifungal prophylaxis; detailed chemotherapy, conditioning and trials for pediatric stem cell transplantation; conditioning granulocyte colony-stimulating factor (G-CSF) in pediatric stem cell transplantation; analyzing prescriptions and programming a pediatric stem cell transplantation; handling chemotherapy and adjuvant drugs for pediatric stem cell transplantation; stem cell transplantation in children up to 1 year old; and clinical pharmacy in pediatric stem cell transplantation. An easy-to-read yet comprehensive guide covering a wide range of topics essential to daily practice, the book offers an invaluable asset for pediatric hemato/ oncology pharmacists, hematologist pharmacists, clinical pharmacists, pediatric pharmacists, pharmaceutical residents and researchers alike.
Contents:
Intro
Foreword
Acknowledgments
Contents
About the Author
Chapter 1: The Pharmacist in Pediatric Hematopoietic Stem Cell Transplantation
Chapter 2: Stem Cells
2.1 General Aspects of Stem Cells
2.2 Types of Stem Cells
2.3 Differentiation and Self-Renew
2.3.1 Differentiation
2.3.2 Progenitor Cells
2.4 Embryonic and Non-embryonic Stem Cells
2.4.1 Embryonic Stem Cells and the Possibility to Use Them in Pediatric Oncology/Hematology
2.5 Basic Concepts on Researching and Handling with Stem Cells
2.5.1 NOD/SCID Mice 3.2.2 Myeloablative, Non-myeloablative, and Reduced-Intensity Pediatric Regimens for Hematopoietic Stem Cell Transplantation
3.3 Autologous Stem Cell Transplantation in Pediatrics
3.3.1 Acute Lymphoid Leukemia (ALL)
3.3.2 Acute Myeloid Leukemia (AML)
3.3.3 Chronic Myeloid Leukemia
3.3.4 Non-Hodgkin Lymphoma
3.3.5 Hodgkin Lymphoma
3.3.6 Solid Tumors
3.3.7 Wilms Tumor
3.3.8 Osteosarcoma
3.3.9 Germ Cell Tumors
3.3.10 Rare Tumors
3.4 Allogeneic Stem Cell Transplantation in Pediatrics
3.4.1 Donors 3.4.2 Risks for the Recipient of Allogeneic Hematopoietic Stem Cell Transplantation Regarding the Sources of Stem Cells
3.4.3 Acute Lymphoid Leukemia (ALL)
3.4.4 Biphenotypic Leukemia
3.4.5 Acute Myeloid Leukemia (AML)
3.4.6 Chronic Myeloid Leukemia
3.4.7 Non-Hodgkin Lymphoma
3.4.8 Hodgkin Lymphoma
3.4.9 Juvenile Myelomonocytic Leukemia, Anemias, Myelodysplasia, Primary Immunodeficiency, and Inborn Error of Metabolism
Chapter 4: Homing of Stem Cells to the Bone Marrow: Finding the Way Home
4.1 Homing
4.1.1 A Big Picture of Homing
4.1.2 Homing First Step 4.1.3 Homing Second Step: Activation of Lymphocyte Function-Associated Antigen 1 (LFA-1), Very Late Antigen 4/5 (VLA-4/5), and CD44
4.1.4 Homing Third Step: Cytoskeleton Rearrangement, Membrane Type 1 (MT1)-Matrix Metalloproteinase (MMP) Activation and Secretion of MMP2/9
4.1.5 Homing Fourth Step: Rolling and Firm Adhesion of Progenitors to Endothelial Cells in Small Marrow Sinusoids Under Blood Flow
4.1.6 Homing Fifth Step: Trans-Endothelial Migration Across the Physical Endothelium/Extracellular Matrix (ECM) Barrier 4.1.7 Homing Sixth Step: Stem Cells Finalize Their Homing by Selective Access and Anchorage to Their Specialized Niches in the Extravascular Space of the Endosteum Region and Periarterial Sites