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  • Book
    edited by Ching-Hon Pui.
    Summary: "In the five years since publication of the second edition of Childhood Leukemias, new insights into the molecular and cellular biology of cancers in general, and of the leukemias in particular, have catalyzed exciting advances in diagnostic methods, strategies of risk assessment and the development of targeted and other novel forms of treatment. Encouraged by this progress, and the enthusiastic responses of readers of the previous edition, I willingly accepted the invitation to develop a third edition of this successful book. The rapid growth in our understanding of the biology of childhood leukemias and the accelerating pace of innovations in diagnostic and therapeutic approaches presented a considerable challenge during revision of the second edition. As you will notice, each chapter has been extensively modified or rewritten to accommodate the most recent information and references. Although structured to emphasize emerging themes in leukemia pathobiology and treatment, the reworked book still seeks to maintain a balance between fundamental pathophysiology and practical approaches to patient management, a standard that was central to the success of our earlier editions. Three chapters are entirely new. One deals with the epigenetics of leukemia, a topic that hasmoved rapidly to the fore of leukemia research. The discovery that aberrant epigenetic changes often cooperate with DNA sequence alterations in the initiation and progression of cancer, and that such changes are potentially reversible, has already led to clinical trials of therapies based on key epigenetic findings"--Provided by publisher. The most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases, from basic science to clinical management.

    Contents:
    Section I. History and General Issues: History of leukemia: historical perspectives / Paul S. Gaynon, Toska J. Zomorodian and Donald Pinkel
    Diagnosis and classification / Mihaela Onciu and Ching-Hon Pui
    Epidemiology and etiology / Logan G. Spector, Bridget Charbonneau and Leslie L. Robison
    Section II. Cell Biology and Pathobiology: Immunophenotyping / Frederick G. Behm
    Immunoglobulin and T-cell receptor gene rearrangements / Jacques J.M. van Dongen and Anton W. Langerak
    Cytogenetics of acute leukemias / Susana C. Raimondi
    Molecular genetics of acute lymphoblastic leukemias / Charles G. Mullighan
    Molecular genetics of acute myeloid leukemia / Tanja A. Gruber and James R. Downing
    Epigenetics of leukemia / William Stevenson and Guillermo Garcia-Manero
    Genetics and cellular drug resistance in acute leukemia / Monique L. den Boer and Rob Pieters
    Heritable predispositions to childhood hematologic malignancies / Alix E. Seif, Beverly J. Lange, Jaclyn A. Biegel, and Kim E. Nichols
    Section III. Evaluation and Treatment:- Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations / Stephen W. Paugh, Mary V. Relling and Williams E. Evans
    Acute lymphoblastic leukemia / Ching-Hon Pui
    Relapsed acute lymphoblastic leukemia / Günter Henze and Arend von Stackelberg
    B-cell acute lymphoblastic leukemia and Burkitt lymphoma / John T. Sandlund and Mihaela Onciu
    Acute myeloid leukemia / Jeffrey E. Rubnitz, Hiroto Inaba and Raul C. Ribeiro. Relapsed acute myeloid leukemia / Ursula Creutzig
    Myelodysplastic syndrome / Henrik Hasle
    Chronic myeloproliferative disorders / Charlotte M. Niemeyer and Franco Locatelli
    Leukemias in patients with Down syndrome / Jeffrey W. Taub, April Sorrell and James A. Whitlock
    Treatment of adolescents and young adults with acute lymphoblastic leukemia / James Nachman
    Hematopoietic stem cell and natural killer cell transplantation / Wing Leung and Michael A. Pulsipher
    Treatment of acute leukemia in countries with limited resources / Raul C. Ribeiro, Scott C. Howard and Ching-Hon Pui
    Antibody-targeted therapy / Alan S. Wayne
    Adoptive cellular immunotherapy / Hyoung Jin Kang, Cliona M. Rooney and Helen E. Heslop
    Gene transfer: methods and applications / Ulrike Gerdemann, Martin Pule and Malcolm K. Brenner
    Development therapeutics / Sima Jeha
    Minimal residual disease / Dario Campana, Andrea Biondi and Jacques J.M. van Dongen
    Section IV. Complications and Supportive Care: Acute complications / Scott C. Howard, Raul C. Ribeiro and Ching-Hon Pui
    Late complications after leukemia therapy / Melissa M. Hudson
    Therapy-related leukemias / Carolyn A. Felix
    Infectious complications in leukemia / Hana Hakim and Patricia M. Flynn
    Hematologic supportive care / Fariba Navid and Victor M. Santana
    Pain management / Doralina L. Anghelescu and Roland Kaddoum
    Psychosocial issues / Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull
    Nursing care / Jami S. Gattuso, Martha May and Michele Chandler.
    Digital Access Cambridge 2012