BookSajal Chakraborti, Tapati Chakraborti, Dhrubajyoti Chattopadhyay, Chandrima Shaha, editors.
Summary: This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.
Contents:
Intro; Preface; Contents; Editors and Contributors; Part I: General Aspects of Oxidant Stress in Microbial Diseases;
1: Role of Reactive Oxygen Species in the Correlation Between Host and Microbes; 1.1 Introduction; 1.2 Involvement of ROS in Cellular Signaling Network; 1.3 ROS Production in Host Cells in Response to Microbial Infection; 1.4 Modulations of Host ROS Level by Pathogenic Microbes; 1.5 Enzymatic Antioxidant System in Microbes Against ROS; 1.6 Intracellular Response by Oxidative Stress; 1.7 Natural Antimicrobial Agent for Controlling Microbial Infection; 1.8 Conclusion 2.3.2.3 Reduced Glutathione (rGSH), Glutathione Peroxidase (GSH-Px), and Glutathione Reductase (GR)2.3.2.4 Catalase; 2.3.2.5 Uric Acid; 2.3.2.6 Vitamin C; 2.4 Biomarkers of Oxidative Stress in Canine Leishmaniosis; 2.4.1 Biomarkers of Oxidant Status; 2.4.1.1 Total Oxidant Status(TOS); 2.4.1.2 Erythrocyte/Plasma Lipid Peroxidation (LPO); 2.4.2 Biomarkers of Antioxidant Status; 2.4.2.1 Total Antioxidant Status (TAS); 2.4.2.2 Paraoxonase-1 (PON-1); 2.4.2.3 Thiols; 2.4.2.4 Superoxide Dismutase (SOD); 2.5 Conclusions; References
3: Reactive Oxygen and Nitrogen Species in the Oral Cavity3.1 Introduction; 3.2 Reactive Oxygen and Nitrogen Species in the Oral Cavity; 3.2.1 Reactive Oxygen Species (ROS); 3.2.2 Reactive Nitrogen Species (RNS); 3.2.3 Oxidative and Nitrosative Stress in Oral Microbial Diseases; 3.2.4 Regulation of Systemic Homeostasis and Dysbiosis by Oral Reactive Oxygen and Nitrogen Species; 3.3 ROS- and RNS-Based Therapeutics; References;
4: Role of Gut Microbiota in Combating Oxidative Stress; 4.1 Introduction; 4.2 Gastrointestinal Tract: Its Influence on Gut Microbiota 4.3 Gut Microbiota: Health and Diseases4.3.1 Early Colonization; 4.3.2 Healthy Gut Microbiota; 4.3.3 Leaky Gut and Dysbiosis; 4.3.4 F/B Ratio: An Important Determinant of Gut Health; 4.3.5 Microbial SCFAs in Combating Oxidative Stress; 4.4 Understanding the Secret World of Microbes: Technological Advancements; 4.4.1 Molecular Techniques; 4.4.2 Sequence-Based Metagenomics; 4.4.3 Choice of Samples and Model System; 4.4.4 Modern High-Throughput Techniques; 4.5 Diseases Inducing Oxidative Stress: Role of Microbiota; 4.5.1 Metabolic Diseases; 4.5.1.1 Obesity; 4.5.1.2 Diabetes