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• Book

  Fc Mediated Activity of Antibodies : Structural and Functional Diversity

  Jeffrey V. Ravetch, Falk Nimmerjahn.

  Summary: This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
  
  Contents:
  IgG Fc receptors: evolutionary considerations
  Role of FcgRs in Antibody Based Cancer Therapy
  Anti-inflammatory Activity of IgG-Fc
  IgG Fc glycosylation in human immunity
  IgE Glycosylation in Health and Disease
  Immune Complex Vaccination
  Fc receptors in anti-microbial protection.

  Digital Access Springer 2019
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• Article

  Francis J. Braceland, the editor--the music will play on.

  Myers ES.

  Am J Psychiatry. 1978 Jul;135(7):789-91.

  Digital Access Access Options
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  PubMed
• Journal

  Archiv für die neuesten Entdeckungen aus der Urwelt.

  Digital Access Full text via HathiTrust, 1.-6. Bd.; 1819-1824.
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