BookJörg Reichrath, Sandra Reichrath, editors.
Summary: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch's role in the development of the embryo to the Notch signaling pathway's role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch's role in senescence, the regulation of Notch signaling by microRNAs, Notch's role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books - Molecular Biology of Notch Signaling and Notch Signaling in Cancer - this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students. -- Provided by publisher.
Contents:
Notch signaling and tissue patterning in embryology : an introduction / Jörg Reichrath, Sandra Reichrath
Notch signalilng and embryonic development : an ancient friend, revisited / Jörg Reichrath, Sandra Reichrath
The five faces of notch signalling during Drosophila melanogaster embryonic CNS development / Epigenetic regulation of notch signaling during Drosophila development / Chuanxian Wei, Chung-Weng Phang, Renjie Jiao
Regulation of proneural wave propagation through a combination of notch-mediated lateral inhibition and EGF-mediated reaction diffusion / Matkoto Sato, Tetsuo Yasugi
A nuclear protein, Nepro, is essential for the maintenance of early neural stem cells and preimplantation embryos / Tetsuichiro Saito
Role of notch signaling in leg development in Drosophila melanogaster / Sergio Córdoba, Carlos Estella
Notch signalling : the multitask manager of inner ear development and regeneration / Nicolas Daudet, Magdalena Żak
Notch pathway and inherited diseases : challenge and promise / Jörg Reichrath, Sandra Reichrath.