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  • Book
    Maurice B. Hallett editor.
    Contents:
    Intro
    Preface
    Contents
    Contributors
    1 An Introduction to Phagocytosis
    Introduction to Phagocytosis
    The Cell Biology of Phagocytosis
    Phagocytosis Dissected
    The Importance of Phagocytosis
    Evolution and Phagocytosis
    Introduction to the Chapters in This Book
    2 A Brief History of Phagocytosis
    Introduction
    Purpose of Chapter
    Let's Start at the Very Beginning
    The Eureka Moment of Metchnikoff
    Inside the Phagocyte
    Phagosomal pH
    Ca2+ Ions and Phagocytosis
    Conclusion
    3 The Role of Membrane Surface Charge in Phagocytosis
    Introduction Lipids That Contribute to Phagocytosis and Phagosome Maturation
    Phospholipid Dynamics and Inner Leaflet Charge During Phagocytosis and Phagosome Maturation
    Role of Electrostatic Interactions in Protein Localization During Phagocytosis and Phagosome Maturation
    Relevance of Inner Leaflet Surface Charge to Phagocytes and Immunity
    Concluding Remarks
    4 Receptor Models of Phagocytosis: The Effect of Target Shape
    Introduction
    Why Modelling?
    Receptor Models of Phagocytosis
    The Basic Receptor Model
    Phagocytosis Versus Other Types of Endocytosis
    The Effect of Target Shape Known Experimental Results
    Modelling Shape Dependence
    Model Extensions and the Future
    Summary
    5 Decision Making in Phagocytosis
    Introduction
    Uptake, Processing, and Release of Long Particles
    Uptake of a Long Particle
    Phagosome Processing
    Release of a Particle
    Myosin-II Does Not Accumulate on the Incipient Phagosome
    Conversion of a Tubular Phagosome into a Bleb
    Simultaneous Uptake and Release of Particles
    Struggle for a Bacterium
    Discussion
    6 Membrane Tension and the Role of Ezrin During Phagocytosis
    Introduction Apparent Expansion of Cell Surface Area During Phagocytosis
    Exocytotic Addition to the Plasma Membrane
    Cell Surface "Wrinkles"
    Membrane Tension and Cell Shape Changes
    Wrinkles and Membrane Tension
    Molecular Maintenance of Membrane Tension
    Ezrin
    Ezrin and Membrane Tension
    Ezrin and Phagocytosis
    Regulation Membrane Tension by Ezrin During Phagocytosis
    Actin Push and the Brownian Ratchet
    Conclusion and Synthesis
    7 Molecular Mechanisms of Calcium Signaling During Phagocytosis
    Abbreviations
    Introduction
    Overview of Ca2+ Signaling
    Phagocytic Ca2+ Signals Ca2+-Permeable Channels Involved in Phagocytic Ca2+ Signals
    ORAI Channels, STIM Proteins and Junctate
    TRPC Channels
    TRPC3
    TRPC4/5
    TRPC6
    TRPM Channels
    TRPM2
    TRPM8
    TRPML Channels
    TRPV Channels
    TRPV1 and TRPV2
    TRPV4
    P2X Channels
    P2X7
    P2X4
    Conclusions and Future Directions
    8 Calpain Activation by Ca2+ and Its Role in Phagocytosis
    Introduction
    Ca2+ in Phagocytosis and Cell Shape Change
    Calpain Activation in Shape Change
    Calpain in Phagocytosis
    Structure of Calpain 1 and 2
    Physiological Activation of Calpain by Ca2+ in Cells Conclusions
    Digital Access Springer 2020