BookMaurice B. Hallett editor.
Contents:
Intro
Preface
Contents
Contributors
1 An Introduction to Phagocytosis
Introduction to Phagocytosis
The Cell Biology of Phagocytosis
Phagocytosis Dissected
The Importance of Phagocytosis
Evolution and Phagocytosis
Introduction to the Chapters in This Book
2 A Brief History of Phagocytosis
Introduction
Purpose of Chapter
Let's Start at the Very Beginning
The Eureka Moment of Metchnikoff
Inside the Phagocyte
Phagosomal pH
Ca2+ Ions and Phagocytosis
Conclusion
3 The Role of Membrane Surface Charge in Phagocytosis
Introduction Lipids That Contribute to Phagocytosis and Phagosome Maturation
Phospholipid Dynamics and Inner Leaflet Charge During Phagocytosis and Phagosome Maturation
Role of Electrostatic Interactions in Protein Localization During Phagocytosis and Phagosome Maturation
Relevance of Inner Leaflet Surface Charge to Phagocytes and Immunity
Concluding Remarks
4 Receptor Models of Phagocytosis: The Effect of Target Shape
Introduction
Why Modelling?
Receptor Models of Phagocytosis
The Basic Receptor Model
Phagocytosis Versus Other Types of Endocytosis
The Effect of Target Shape Known Experimental Results
Modelling Shape Dependence
Model Extensions and the Future
Summary
5 Decision Making in Phagocytosis
Introduction
Uptake, Processing, and Release of Long Particles
Uptake of a Long Particle
Phagosome Processing
Release of a Particle
Myosin-II Does Not Accumulate on the Incipient Phagosome
Conversion of a Tubular Phagosome into a Bleb
Simultaneous Uptake and Release of Particles
Struggle for a Bacterium
Discussion
6 Membrane Tension and the Role of Ezrin During Phagocytosis
Introduction Apparent Expansion of Cell Surface Area During Phagocytosis
Exocytotic Addition to the Plasma Membrane
Cell Surface "Wrinkles"
Membrane Tension and Cell Shape Changes
Wrinkles and Membrane Tension
Molecular Maintenance of Membrane Tension
Ezrin
Ezrin and Membrane Tension
Ezrin and Phagocytosis
Regulation Membrane Tension by Ezrin During Phagocytosis
Actin Push and the Brownian Ratchet
Conclusion and Synthesis
7 Molecular Mechanisms of Calcium Signaling During Phagocytosis
Abbreviations
Introduction
Overview of Ca2+ Signaling
Phagocytic Ca2+ Signals Ca2+-Permeable Channels Involved in Phagocytic Ca2+ Signals
ORAI Channels, STIM Proteins and Junctate
TRPC Channels
TRPC3
TRPC4/5
TRPC6
TRPM Channels
TRPM2
TRPM8
TRPML Channels
TRPV Channels
TRPV1 and TRPV2
TRPV4
P2X Channels
P2X7
P2X4
Conclusions and Future Directions
8 Calpain Activation by Ca2+ and Its Role in Phagocytosis
Introduction
Ca2+ in Phagocytosis and Cell Shape Change
Calpain Activation in Shape Change
Calpain in Phagocytosis
Structure of Calpain 1 and 2
Physiological Activation of Calpain by Ca2+ in Cells Conclusions