BookChun-Feng Liu, editor.
Summary: This book focuses on the sleep-related disorders in Parkinson's disease (PD), demonstrating that they are among the most common non-motor manifestations of PD and have a significant negative impact on quality of life. Sleep changes may also serve as markers to identify patients in the preclinical stage of PD. This book presents recent major breakthroughs related to sleep disorders in PD, such as REM sleep behavior disorder (RBD), insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. It also discusses the epidemiology, etiology, diagnosis, clinical implications, associated features, evaluation and management of these disorders and suggests some further research directions in these areas in order to develop neuroprotective therapies for PD. Focusing on Chinese PD patients, it addresses traditional Chinese Medicine, and compares the epidemiology and management of PD in China and Western countries to provide a frame of reference values for further studies. Further, it features numerous case reports to enable readers gain a better uderstanding of the subject matter. This comprehensive yet practical book is a valuable resource for scientists and clinicians.
Contents:
Intro
Preface
Acknowledgments
Contents
Part I: General Concepts
1: An Overview of Parkinson's Disease
2: An Overview of Roles of the Basal Ganglia in Sleep-Wake Regulation
2.1 Introduction
2.2 The Roles of the BG in the Sleep-Wake Cycle
2.3 The Role of the Dopaminergic and Adenosinergic System in the BG in the Sleep-Wake Cycle
2.4 A Model of NAc Involvement in Sleep-Wake Regulation
References
Part II: Classification of Sleep Disorders in Parkinson's Disease
3: REM Sleep Behavior Disorder (RBD)
3.1 Case Report
References
4: Insomnia 4.1 Introduction
4.2 Prevalence of Insomnia in Parkinson's Disease
4.3 Risk Factors of Insomnia in Parkinson's Disease
4.4 Etiologic Mechanisms of Insomnia in Parkinson's Disease
4.5 Clinical Manifestations of Insomnia in Parkinson's Disease
4.6 Diagnostic Criteria and Instruments of Insomnia in Parkinson's Disease
4.7 Treatment of Insomnia in Parkinson's Disease
4.8 Concluding Remarks
4.9 Case Report
4.9.1 Clinical Feature
4.9.2 Past History, Family History and Personal History
4.9.3 Physical Examination 4.9.4 Imageological Examination and Scale Assessment
4.9.5 Polysomnography (PSG)
4.9.6 Diagnosis
4.9.7 Treatment
4.9.7.1 Sleep Hygiene
4.9.7.2 Muscle Relaxation Therapy
4.9.7.3 Medication
References
5: Nocturia
5.1 Introduction
5.2 Causes for Nocturia in PD
5.2.1 Reduced Bladder Capacity
5.2.2 Nocturnal Polyuria
5.2.3 Circadian Rhythm Disturbances
5.2.4 Other Possible Mechanism for Nocturia in PD
5.3 Diagnosis and Evaluation of Nocturia in PD [14]
5.3.1 History Taking and Physical Examination
5.3.2 Investigation 5.3.2.1 Routine Test
5.3.2.2 Ultrasonography
5.3.2.3 Urodynamics
5.3.2.4 Other Investigations
5.4 Management and Treatment of Nocturia in PD
5.4.1 Pharmacological Interventions
5.4.1.1 Dopamine Agonists
5.4.1.2 Antimuscarinic Agents
5.4.1.3 Desmopressin
5.4.1.4 Melatonin
5.4.2 Intermittent Catheterization
5.4.3 Botulinum Toxin Injection
5.4.4 Surgical Treatment
5.4.5 Neuromodulation
5.4.6 Lifestyle Change
References
6: Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder
6.1 Introduction 6.2 The Association Between PD and RLS
6.3 Genetic Markers of RLS in PD
6.4 Pathophysiology of RLS in PD
6.5 Imaging of RLS in PD
6.6 Diagnosis of RLS in PD
6.7 Treatment of RLS in PD
References
7: Sleep-Related Breathing Disorders
7.1 Introduction
7.2 Causes of SBD in PD
7.3 Diagnosis [11]
7.3.1 History Taking and Physical Examination
7.3.2 Investigations
7.4 Treartment [14, 15]
7.4.1 Lifestyle Change
7.4.2 Medication
7.4.3 Continuous Positive Airway Pressure Therapy (CPAP)
References
8: Excessive Daytime Sleepiness