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- ArticlePoole-Wilson PA, Langer GA.Am J Physiol. 1979 Apr;236(4):H525-33.The effects of acidosis on myocardial function and calcium exchange have been studied in the isolated but arterially perfused interventricular septum of the rabbit. Temperature was 28 degrees C and stimulation rate 48 beats/min. Acidosis was induced either by increase of the perfusate PCO2 (pH reduced from 7.35 to 6.68) or by decrease of the bicarbonate-chloride ratio (pH 7.35 to 6.72). The effect on calcium efflux was assessed by introduction of acidosis at different times during the washout of 45Ca2+ from the muscle. The uptake of 47Ca2+ was recorded directly with a NaI crystal and counter. An increase of perfusate PCO2 caused a rapid fall in developed tension. The efflux of slowly exchanging 45Ca2+ and the uptake of 47Ca2+ were inhibited. There was no rapid displacement of calcium from the muscle. Decrease of the bicarbonate-chloride ratio caused a slower fall of developed tension and neither the efflux nor uptake of calcium were altered. These results suggest that developed tension and calcium exchange in the myocardium are more responsive to acidosis within the cell or cell membrane than to extracellular acidosis.
- Bookvon Karl von den Steinen ... Mit 30 tafeln (1 heliogravüre, 11 lichtdruckbilder, ... Show More 5 autotypien und 7 lithogr. tafeln), sowie 160 text-abbildungen nach den photographien der expedition, nach den originalaufnahmen von Wilhelm von den Steinen und nach zeichnungen von Johannes Gehrts nebst einer karte von prof. dr. Peter Vogel.Digital Access Full text via HathiTrust, 1894
- Bookpræside Dn. Jacobo Reinboldo Spielmann ... Solemni eruditorum disquisitioni offert D. XXV. Januarii MDCCLXXXI ; Thomas Lauth Argentinensis auctor H.L.Q.C.PrintLocationVersionCall NumberItems