BookSteven Piantadosi.
Contents:
Preliminaries
Clinical Trials as research
Why Clinical Trials are ethical
Context for Clinical Trials
Context for clinicak tricals
Measurement
Random error and bias
Statistical perspectives
Experiment design in clinical trials
The trial cohort
Development paradigms
Translational clinical trials
Early development and dose-finding
Middle Development
Comparative trials
Adaptive design features
Sample size and power
Treatment allocation
Treatment effects monitoring
Counting subjects and events
Estimating clinical effects
Prognostic factor analyses
Factorial design
Crossover Designs
Meta-analyes
Reporting and authorship
Misconduct and fraud in clinical research
Appendix A Data and programs
Appendix B Abbreviations
Appendix C Notation and Terminology
Appendix D Nuremberg code
References
Index.