BookSisko Anttila, Paolo Boffetta, editors.
Summary: This up-to-date review of the literature on the epidemiology and pathology of work-related cancers also includes sensitive diagnostic questionnaires and data on the risk ratios of differing cancers in relation to a variety of occupations and lifestyle factors.
Contents:
Intro
Foreword
A Cartography of Occupational Cancer Prevention
References
Preface
Acknowledgments
Contents
1: Historical Overview of Occupational Cancer Research
Early Discoveries
How Evidence Has Been Accumulated on Selected Associations
Sources of Evidence on Risk to Humans Due to Chemicals
Epidemiology
Animal Experimentation
Short-Term Tests and Structure-Activity Relationships
Listing Occupational Carcinogens
IARC Monographs
Definite and Probable Occupational Risk Factors for Cancer
The Evolution of Knowledge
Interpreting the Lists Illustrative Examples and Controversies
Polycyclic Aromatic Hydrocarbons (PAHs)
Diesel and Gasoline Engine Emissions
Asbestos
Cadmium and Cadmium Compounds
Styrene
1,3-Butadiene
Vinyl Chloride
Radium and Radon
Some Methodological Considerations
Industry-Based Studies
Community-Based Case-Control Studies
Some Trends in Epidemiologic Research on Occupational Cancer
Continued Importance of Research on Occupational Cancer
References
2: Genetics, Epigenetics, and Environmental Interactions
Genetics and Heritability
Phenotype Versus Genotype Epigenetics
DNA Methylation
Histone Modifications
Non-coding RNA
microRNA
Long Non-coding RNA
Bringing Together the Concepts of Genetics, Epigenetics, and Phenotype
Gene-Environment Interactions
Xenobiotic Metabolism and Excretion
Phase I Polymorphisms and Cancer
Phase II Polymorphisms and Cancer
Other Polymorphisms and Cancer
Population Stratification
Gene-Gene Interactions
Genome-Wide Association Studies (GWAS)
Epigenetics and Environmental/Occupational Exposure
Summary
References 3: Mechanisms of Environmental and Occupational Carcinogenesis
Environmental and Occupational Carcinogenesis
Field Cancerization and Expanding Fields
Environmental and Occupational Sources of DNA Damage
Physical Carcinogens
Chemical Carcinogenesis
Endogenous Mechanisms Activated by Exogenous Exposures
DNA Repair
Direct Reversal Repair
Base Excision Repair
Nucleotide Excision Repair
Mismatch Repair
Interstrand Cross-Link Repair
Double-Strand DNA Break Repair
DNA Damage Tolerance
Apoptosis
Genetic Mutations
Epigenetics and Cancer DNA Methylation and Cancer
Environmental and Occupational Epigenetic Effectors
Histone Modification
CpG Methylation and Point Mutations
Somatic Mutations in Epigenetic Regulators
Inflammation and Reactive Oxygen Species
Endocrine Disruption
References
4: Head and Neck Cancers
Introduction
Descriptive Epidemiology
Nasopharynx Cancer
Nonoccupational Risk Factors
Occupational Risk Factors
Oral and Pharyngeal Cancers
Occupations and Agents with Less Than Sufficient Evidence
Formaldehyde
Wood Dust and Wood Industry Work