BookMauro Monteiro Correia, Michael A. Choti, Flavio G. Rocha, Go Wakabayashi, editors.
Contents:
Intro
Preface
Contents
Contributors
1: Surgical Treatment of Colorectal Cancer Liver Metastases (CRLM)
Historical Aspects
References
2: The Biology of Colorectal Liver Metastases
Introduction
Colorectal Carcinogenesis
Colon Cancer Stem Cells and the Hierarchical Organization Model
CRC Molecular Classification Subtypes and the Role of Stroma
Endothelial Cells and Angiogenesis
Epithelial-Mesenchymal Transition (EMT) and Colorectal Cancer (CRC): Extravasation
Circulating Tumor Cells (CTCs)
Extravasation and Metastatic Dormancy
Immune System Conclusion
References
3: Molecular Biomarkers for the Management of Colorectal Cancer Liver Metastases
Introduction
KRAS
BRAF
TP53
PIK3CA
APC
SMAD4
Microsatellite Instability
Circulating Tumor Cells
Conclusion
References
4: Diagnosis of Colorectal Liver Metastases
Definition
Follow-Up After Treatment of the Primary Tumor
Clinical Diagnosis
Laboratory Diagnosis
Biological Diagnosis
Imaging Diagnosis
Methods
Ultrasonography
Contrasted Ultrasonography
Computed Tomography
Positron Emission Computed Tomography (PET-CT) Magnetic Resonance Imaging
Magnetic Resonance with Specific Hepatobiliary Contrast
Intraoperative Ultrasound
Typical Presentation of Hepatic Colorectal Metastases
Particular Situations
Small Hepatic Lesions
Neoadjuvant Chemotherapy Imaging Workup
Final Recommendation
References
5: Role of Imaging in the Management of Patients with Potentially Resectable CRLM
Introduction
Role of Imaging in Detection of CRLM
Ultrasound
Computed Tomography (CT)
Magnetic Resonance Imaging (MRI)
Positron Emission Tomography (PET) Role of Imaging in Surgical Planning for CRLM
Vascular Assessment
Liver Volumetry
Conclusion
References
6: Staging Classifications of Colorectal Liver Metastases
Introduction
Prognostic Factors for CRLM Patients Undergoing Liver Resection
Staging System for CRLM
TNM Cancer Staging System for Colon and Rectum Cancer
Japanese Staging System for CRLM
Risk Scoring Systems for CRLM Patients Undergoing Liver Resection
Validation Study of Risk Scoring Systems for CRLM Patients Treated with Liver Resection
New Aspects of the Prognostic Score System Nomogram to Predict Prognosis of Resected CRLM
Conclusion
References
7: Prognostic Factors of Colorectal Cancer Liver Metastasis
Introduction
Factors Related to the Patient
Factors Related to Primary Tumor
Factors Related to Liver Tumor
Conclusion
References
8: Clinical Scoring Systems for Colorectal Cancer Liver Metastases
9: What Is the Impact of Positive Margins in the Liver?
Introduction
Early Scoring Systems
Contemporary Scoring Systems
Validation and Comparison of Existing Scoring Systems
Should I Use a Scoring System? If So, Which One? When Should I Use a Scoring System?
Conclusion
References