BookJun Cui, editor.
Summary: This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins. In the past decade, there have been major advances in our understanding of the molecular mechanisms of autophagy and its physiological functions. This book highlights emerging studies on the underlying mechanisms of autophagy regulation of innate immunity, including inflammation, antiviral immunity and anti-bacterial responses and the signaling pathways that prompt or inhibit the initiation and progression of related diseases. It also offers new ideas and strategies for future drugs based on manipulating autophagy, especially selective autophagy mediated by cargo receptors. Providing a comprehensive overview of the autophagy regulation of innate immunity, it is a valuable resource for graduate students and researchers in the fields of immunology, cell biology and translational medicine.
Contents:
Introduction
Autophagy Regulation of Mammalian Immune Cells
Autophagy in Plant Immunity
Autophagy Regulation of Bacterial Pathogen Invasion
Autophagy and viral infection
The Interplay between Pattern Recognition Receptors and Autophagy in Inflammation
Regulation of Inflammasome by Autophagy
The Cross-regulation between Autophagy and Type I Interferon Signaling in Host Defense
Selective Autophagy Regulates Innate Immunity through Cargo Receptor Network
Autophagy and Immune-related Diseases
Targeting Autophagy with Small-molecule Modulators in Immune-related diseases.