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- BookPetros Efthimiou, editor.Summary: This book provides a concise and up-to-date review of key rheumatology topics along with extensive practice questions to assist in preparing for the American Board of Internal Medicine (ABIM) Rheumatology Certification Exam. Each chapter focuses on a single disease and starts with a short review (primarily tables and figures) to highlight the main points and key issues. The review is followed by 10-20 board-style multiple choice questions with detailed explanations for each topic. The chapters and associated preparation questions are written by established experts from top institutions in the United States. The book concludes with a 50-question practice test reflecting the format used by the ABIM Board Certification Exam. Absolute Rheumatology Review is an essential resource for not only graduate students, residents, and fellows in rheumatology and internal medicine studying for board exams but also rheumatologists, physicians, and related professionals preparing for recertification.
Contents:
Introduction.-Immunological Basis of Inflammatory Arthritides
Clinical Epidemiology for Rheumatologists
Osteoarthritis
Regional Musculoskeletal Syndromes and the use of MSK Ultrasound
Infectious Arthritis
Rheumatoid Arthritis.-Psoriatic Arthritis
Axial Spondyloarthritis
Systemic Lupus Erythematosus
Sjogren's Syndrome
Systemic Sclerosis (Scleroderma)
Vasculitis
Inflammatory Myopathies
Osteoporosis
Crystal Arthritis.-Autoinflammatory Diseases
Pediatric Rheumatology for Adult Rheumatologists.-Musculoskeletal Manifestations of Systemic Diseases
Clinical Genetics in Rheumatology. - ArticlePinney RJ, Hernadi F, Smith JT.Chemotherapy. 1978;24(4):240-8.Hydroxyurea (HU) and cytosine arabinoside (Ara-C) eliminate R factor R46 from Escherichia coli strain J5-3. The highest frequency of elimination for both drugs occurred at concentrations and times that produced the lowest survivor levels. 5% of cells were antibiotic-sensitive after 5 h incubation in 5 mg/ml Ara-C, whilst 6 and 7% of the survivors had lost the R factor after 8 and 24 h incubation, respectively in 20 mg/ml HU. The number of survivors began to increase after 5 h incubation in Ara-C, probably due to the inactivation of the drug in the phosphate-buffered medium. All four antibiotic resistances (ampicillin, streptomycin, sulphonamide and tetracycline) mediated by R46 were lost simultaneously and elimination of the whole plasmid was confirmed by conjugation experiments in which the 'cured' cells was shown to be as efficient recipients of R46 as the control R- strain in crosses with E. coli strain J6-2 (R46). No covalently closed circular plasmid DNA was demonstrable in cured cell lines. R+ and R- strains had similar sensitivities to HU but J5-3 R+ was much more sensitive to Ara-C than the isogenic R- strain. It may be concluded that HU eliminates R46 actively whereas although Ara-C may produce some active elimination it acts mainly by selection of R- cells present in the culture.