BookFrank L. Tornatore, John J. Sramek, Bette L. Okeya, Edmond H. Pi.
Summary: After thousands of clinical trials, the efficacy of psychotropic drugs in the treatment of psychiatric disorders has become well established. However, the very success of these drugs has meant that many patients with chronic illnesses will receive them for a significant part of their lifetime. Side effects and other adverse reactions are an unfortunate but unavoidable component of successful pharmacotherapy. In deed, the main emphasis in new drug development is often on the search for compounds that have fewer side effects, although no one has as yet found an effective drug without them. Therefore, it is important for clinicians to be aware of side effect reaction profiles, because they are often a major determining factor in the choice of therapy. After more than three decades of major breakthroughs in the development of psychotropic drugs, reactions to these medications are still frequently reported in the current liter ature, and information about well-known reactions is con stantly refined. This book is an attempt to systematically collect and organize this large body of data and present it in an easy-to-use form. All chapters follow the same reaction oriented logic, and each important reaction is discussed using the same consistent subdivisions. The more clinically impor tant reactions appear in the body of each chapter; the more unusual or rarely reported reactions are briefly characterized in the miscellaneous section at the end of each chapter.
Contents:
1. Reactions to Antipsychotics
Autonomic Effects
Cardiovascular Effects
Dermatological Effects
Hematological Effects
Hepatic Effects: Jaundice
Metabolic and Endocrine Effects
Neuroleptic Malignant Syndrome
Neurological Effects
Ocular Abnormalities
Pregnancy: Teratogenicity
Renal Effects
Sudden Death
Syndrome of Inappropriate Antidiuretic Hormone
Miscellaneous Effects
2. Reactions to Antidepressants: Tricyclic and Tetracyclic
Anticholinergic Effects
Blood Dyscrasias
Cardiovascular Effects
Dermatological Effects
Endocrine Effects
Hepatic Effects
Neurological Effects
3. Reactions to Antidepressants: Monoamine Oxidase Inhibitors
Cardiovascular Effects
Endocrine Effects
Hepatic Effects
Neurological Effects
Withdrawal Effects
Miscellaneous Effects
4. Reactions to Lithium
Dermatological Effects
Cardiovascular Effects
Gastrointestinal Effects
Hematological Effects (Leukocytosis)
Renal Effects
Teratogenic Effects
Thyroid Effects (Hypothyroidism)
Tremor
Weight Gain
Withdrawal Effects
Miscellaneous Effects
5. Reactions to Benzodiazepines
Behavioral Effects
Cardiovascular Effects
Respiratory Effects
Teratogenic Effects
Withdrawal and Tolerance Effects
Miscellaneous Effects
6. Reactions to Antiparkinson Agents
Autonomic Effects
Euphoric Effects
Teratogenic Effects
Miscellaneous Effects
7. Major Psychotropic Drug Interactions
Antipsychotics
Antidepressants
Lithium
Benzodiazepines
Suggested Readings.