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  • Book
    Xiaodong Liu, Guoyu Pan, editors.
    Contents:
    Intro; Preface; Contents; Contributors;
    Chapter 1: Overview: Role of Drug Transporters in Drug Disposition and Its Clinical Significance; 1.1 General Consideration; 1.2 Physiological Roles of Drug Transporters; 1.3 Roles of Drug Transporters in Inter-organ Communication; References;
    Chapter 2: ABC Family Transporters; 2.1 Introduction; 2.1.1 General Properties of ABC Transporters; 2.1.2 Overview of Human ABC Gene Subfamilies; 2.1.2.1 ABCA Family; 2.1.2.2 ABCB Family; 2.1.2.3 ABCC Family; 2.1.2.4 ABCD Family; 2.1.2.5 ABCG Family; 2.2 P-Glycoprotein (P-GP/ABCB1) 2.2.1 General Properties and Distribution of P-GP2.2.2 Substrates and Inhibitors of P-GP; 2.2.3 Physiological and Pharmacological Functions of P-GP; 2.2.3.1 Function of P-GP at Blood-Brain Barrier; 2.2.3.2 Function of P-GP at Fetal-Maternal Barrier Function; 2.2.3.3 Function of P-GP at Hepatobiliary Excretion; 2.2.3.4 Function of P-GP in Restricting Oral Bioavailability of Drugs; 2.2.3.5 P-GP Function in the Kidney; 2.2.3.6 P-GP Function in Immune System; 2.2.4 Pharmacological Significance of P-GP Inhibition; 2.2.5 ABCB1 Polymorphisms and P-GP Expression/Function 2.3 Multidrug Resistance-Associated Proteins (MRPs/ABCCs)2.3.1 Multidrug Resistance-Associated Protein 1 (MRP1/ABCC1); 2.3.1.1 General Properties and Distribution of MRP1; 2.3.1.2 Substrates and Inhibitors of MRP1; 2.3.1.3 Pharmacological Functions of MRP1; 2.3.2 Multidrug Resistance Protein 2 (MRP2/ABCC2); 2.3.2.1 General Properties and Distribution of MRP2; 2.3.2.2 Substrates and Inhibitors of MRP2; 2.3.2.3 Pharmacological and Toxicological Functions of MRP2; 2.3.3 Multidrug Resistance Protein 3 (MRP3/ABCC3); 2.3.3.1 General Properties of MRP3 2.3.3.2 Pharmacological and Physiological Functions of MRP32.3.4 Multidrug Resistance Protein 4 (MRP4/ABCC4); 2.3.4.1 General Properties of MRP4; 2.3.4.2 Pharmacological and Physiological Function of MRP4; 2.3.5 Other Multidrug Resistance Proteins; 2.3.5.1 Multidrug Resistance Protein 5 (MRP5); 2.3.5.2 Multidrug Resistance Protein 6 (MRP6/ABCC6); 2.3.5.3 Multidrug Resistance Protein 7 (MRP7/ABCC10); 2.3.5.4 Multidrug Resistance Protein 8 (MRP8/ABCC11); 2.4 Breast Cancer Resistance Protein (BCRP/ABCG2); 2.4.1 General Properties and Distribution of BCRP; 2.4.2 Substrates and Inhibitors of BCRP 2.4.3 Pharmacological and Physiological Functions of BCRP2.4.3.1 Roles of BCRP in Disposition and Toxicity/Efficacy of Drugs; 2.4.3.2 BCRP and Side Population; 2.4.3.3 BCRP and Alzheimerś Disease; 2.4.3.4 BCRP and Hyperuricemia; 2.4.3.5 BCRP and Cancer; 2.5 ABC Genes and Human Genetic Disease; 2.5.1 Cystic Fibrosis and CFTR; 2.5.2 Adrenoleukodystrophy; 2.5.3 Sulfonylurea Receptor; 2.5.4 Bile Salt Transport Disorders; 2.5.5 Retinal Degeneration and ABCA4; 2.5.6 Mitochondrial Iron Homeostasis; 2.5.7 Sterol Transport Deficiencies; References;
    Chapter 3: SLC Family Transporters 3.1 General Introduction
    Digital Access Springer 2019