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  • Book
    Nik Sheng Ding, Peter De Cruz, editors.
    Summary: This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.

    Contents:
    Part I: Introduction
    nflammatory bowel disease – more than meets the eye
    Clinical risk factors – lessons from epidemiology
    Clinical trial design for biomarker discovery
    Database/ big data meets real world
    Patient reported outcomes
    Part II: Biomarkers – Prognostic vs Predictive
    Biomarkers for remote monitoring
    Disease modification
    Part IIV: Crohns disease
    Luminal Crohns disease-. Perianal CD
    Fibrosis/ strictures in CD
    Post-op Crohns disease
    Part IV: Ulcerative colitis
    UC surveillance
    Acute severe UC
    Chronic active UC
    Pouchitis
    Refractory proctitis
    Feacal microbiota transplantation
    Primary sclerosing cholangitis
    Extraintestinal manifestations of IBD
    Part V: Specialised scenarios
    Pregnancy
    Nutrition
    TDM
    Biomarkers to quantify immune response
    Drug toxicity
    Part VI:Scientific
    Exposome and diet
    Microbiota
    Metabonomics
    Immunology
    Genomics
    Systems Biology in Biomarker research
    Part VII: Ideal tools for investigation in the future.
    Digital Access Springer 2019