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  • Book
    [edited by] Deborah Dang, PhD, RN, NEA-BC, Sandra L. Dearholt, MS, RN, NEA-BC.
    Summary: "This fully revised third edition builds on the strength of the first two editions with updated content based on more than a decade of the model’s use and refinement in real-life settings."--Back cover.

    Contents:
    Evidence-based practice : context, concerns, and challenges
    Critical thinking and evidence-based practice
    The Johns Hopkins Nursing evidence-based practice model and process overview
    The practice question
    Searching for evidence
    Evidence appraisal : research
    Evidence appraisal : non-research
    Translation
    Creating a supportive EBP environment
    Exemplars
    Using the JHNEBP tools.
    Digital Access R2Library 2018
    Limited to 2 simultaneous users
  • Article
    Karlsson E.
    Clin Pharmacokinet. 1978 Mar-Apr;3(2):97-107.
    Procainamide is almost completely absorbed after oral administration and peak plasma concentrations are generally reached within 1 to 2 hours. Upon intravenous administration there is a rapid initial distribution phase, which is completed after about 30 minutes. The pharmacokinetics can be described by a 2-compartment open model. The plasma half-life during the beta-phase averages 3 hours. The apparent volume of distribution is about 2L/kg body weight. At therapeutic plasma levels about 15% is bound to plasma proteins. Approximately 50% of administered procainamide is eliminated as unchanged drug via the kidneys. N-Acetylprocainamide is the main metabolite and is the main metabolite and is pharmacologically active, with a recovery in urine of about 15% (range 7 to 34% in healthy subjects). The acetylation of procainamide seems to be under the same monogenic control as that of isoniazid. At least 2 more metabolites have been found but are not yet identified. The renal clearance of procainamide ranges from 179 to 660ml/min. Glomerular filtration and active tubular secretion seem to be the most important mechanisms. In patients with low-output cardiac and/or renal impairment, the absorption, distribution and elimination of the drug may be significantly altered. Determination of plasma levels is of particular value in these cases and will contribute to more safe and effective therapy in the majority of patients. As N-acetylprocainamide seems to have pharmacological effects comparable with those of procainamide, both agents should be monitored simultaneously in order to optimise therapy.
    Digital Access Access Options