BookMohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors.
Summary: This book examines vital considerations in designing effective translational strategies in the development of antibody-based therapeutics, including the relationship between the 'unit dose' and 'unit effect' with respect to beneficial and deleterious effects.
Contents:
Introduction
Translational considerations and challenges : an overview
Considerations for construct and affinity design goals
Epitope characterization and isotype selection
Biophysical considerations for development of antibody-based therapeutics
Novel technologies for generation of bispecific constructs
Stimulus-response mechanisms : an overview
Evaluation of tumor growth inhibition in preclinical tumor models : a quantitative approach
Application of proof-of-mechanism biomarkers (POM) in design and development of biologics modalities
Antibody drug conjugates : translational considerations
Application of PK-PD modeling and simulation approaches for immuno-oncology drugs
Translational biomarkers : application in the clinical development of combination therapies
Correction to : considerations for construct and affinity design goals.