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  • Book
    Giuseppe Biondi-Zoccai, editor.
    Summary: This book is the first exclusively devoted to the systematic synthesis of accuracy studies. It builds upon the major recent developments in reporting standards, search methods, and, in particular, statistical tools specifically devoted to diagnostic studies. In addition, it borrows extensively from the latest advances in systematic reviews and meta-analyses of intervention studies. After a section dedicated to methods for designing reviews, synthesizing evidence and appraising inconsistency in research, the application of these approaches is demonstrated in the context of case studies from various clinical disciplines. Diagnosis is central in medical decision-making, and in many other fields of human endeavor, such as education and psychology. The plurality of sources of evidence on diagnostic test accuracy poses a huge challenge for practitioners and researchers, as do the multiple dimensions of evidence validity, which include sensitivity, specificity, predictive values, and likelihood ratios. This book offers an invaluable resource for anyone aiming to improve decision-making processes in diagnosis, classification or risk prognostication, from epidemiologists to biostatisticians, radiologists, laboratory physicians and graduate students, as any physician interested in refining his methodological skills in clinical diagnosis.

    Contents:
    SECTION I
    1. Introduction to Clinical Diagnosis
    2. The Evidence Hierarchy
    3. Peculiarities of Diagnostic Test Accuracy Studies
    4. Meta-analyses of Clinical Trials vs Diagnostic Test Accuracy Studies
    SECTION II
    5. Designing the Review
    6. Registering the review
    7. Searching for Diagnostic Test Accuracy Studies
    8. Abstracting Evidence
    9. Appraising Evidence
    10. Synthesizing Evidence
    11. Appraising Heterogeneity
    12. Statistical Packages and Diagnostic Meta-analysis and Their Application
    13. Network Meta-analysis of Diagnostic Test Accuracy Studies
    14. Transition to Intervention Meta-analysis
    15. Updating Diagnostic Test Accuracy Systematic Reviews: Which, When and How Should They be Updated?
    SECTION III
    16. Diagnostic Meta-Analysis: Case Study in Endocrinology
    17. Diagnostic Meta-Analysis: Case Study in Gastroenterology
    18. Diagnostic Meta-Analysis: Case Study in Oncology
    19. Diagnostic Meta-analysis: Case Study in Surgery
    SECTION IV
    20. Avenues for Further Research
    21. Conclusion.
    Digital Access Springer 2018