Live Chat
Today's Hours: 8:00am - 10:00pm
Lane Medical Library

Search

Filter Results

Did You Mean:

Search Results

Sort by
relevance
  • Book
    Akihiko Yoshimura, editor ; responsible series editor: Tasuku Honjo.
    Summary: "This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to 'molecules and cells that negatively regulate T-cell activation'. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike." -- Back cover.

    Contents:
    Regulatory T cells: molecular and cellular basis for immunoregulation
    Overview of LAG-3-expressing, IL-10-producing regulatory T cells
    Regulatory dendritic cells
    Role of PD-1 in immunity and diseases
    CTLA-4, an essential immune-checkpoint for T cell activation
    Tim-3, Lag-3, and TIGIT
    SOCS1: regulator of T cells in autoimmunity and cancer
    Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity
    Immune regulation by ubiquitin tagging as checkpoint code
    MicroRNA in immune regulation.
    Access via Current topics in microbiology and immunology ; 2017; 410.
    Location
    Version
    Call Number
    Items
    Current topics in microbiology and immunology ; 2017; 410.
    2017
  • Book
    Department of International Economic and Social Affairs.
    Contents:

    v. 1. Methods for comprehensive planning. module 1. Conceptual issues and methods for preparing demographic projections. module 3. Techniques for preparing projections of household and other incomes, household consumption and savings and government consumption and investment.
    Print 1989-
  • Article
    Neeff J, Mecke D.
    Arch Microbiol. 1977 Oct 24;115(1):55-60.
    The cytoplasmic malate dehydrogenase in the yeast Saccharomyces cerevisiae is known to be inactivated by a glucose dependent process. In this paper it is shown that in vivo effectors of the glucose metabolism (arsenate, iodoacetate, acetaldhyde) inhibit the inactivation or change the inactivation kinetics. In vitro it was possible to inactivate the malate dehydrogenase by addition of the glucose metabolite glyceraldehyde 3-phosphate. The physiological relevance of this modification and the effect of malate dehydrogenase inactivation on the glyoxylate cycle in yeast is discussed.
    Digital Access Access Options