Bookedited by Takeo Kubota, Hideoki Fukuoka.
Summary: This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.
Contents:
Part I. Biological Basis
One-carbon metabolism and lipid metabolism in DOHaD
Novel models of epigenetic gene regulation in the nutritional environment
Epigenetic switching and neonatal nutritional environment
Part II. Disease and Environment
Developmental origins of nonalcoholic fatty liver disease (NAFLD)
Fetal origins of hypertension
Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOHaD theory
Part III. Transgenerational Mechanism and Its Consequences
Placental development and nutritional environment
Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm
Part IV. Clinical Significance
Preemptive epigenetic medicine based on fetal programming.