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  • Book
    edited by Roderic G. Eckenhoff, Ivan J. Dmochowski.
    Contents:
    Part A: Chapter One: Physical Accuracy Leads to Biological Relevance: Best Practices For Simulating Ligand-Gated Ion Channels Interacting with General Anesthetics / Sruthi Murlidaran, Grace Brannigan
    Chapter Two: Computational Approaches to Studying Voltage-Gated Ion Channel Modulation by General Anesthetics / Eleonora Gianti, Vincenzo Carnevale
    Chapter Three: Molecular Mechanics Parameterization of Anesthetic Molecules / Thomas T. Joseph, Jérôme Hénin
    Chapter Four: Insights Into Receptor-Based Anesthetic Pharmacophores and Anesthetic-Protein Interactions / Victoria S. Fahrenbach, Edward J. Bertaccini
    Chapter Five: Understanding Anesthetic Mechanisms: Analysis of the Complex Kinetics of Ligand-Gated Ion Channels / Robert S. Cantor
    Chapter Six: General Genetic Strategies / Louise M. Steele, Philip G. Morgan
    Chapter Seven: Approaches to Anesthetic Mechanisms: The C. elegans Model / Louise M. Steele, Margaret M. Sedensky
    Chapter Eight: Using Drosophila to Understand General Anesthesia: From Synapses to Behavior / Shanker Karunanithi, Michael Troup, Bruno van Swinderen
    Chapter Nine: High-Throughput Screening to Identify Anesthetic Ligands Using Xenopus laevis Tadpoles / Kellie A. Woll, Roderic G. Eckenhoff
    Chapter Ten: Zebrafish: A Pharmacogenetic Model for Anesthesia / Victoria Bedell, Elena Buglo, Daniel Marcato, Christian Pylatiuk, Ralf Mikut, Johannes Stegmaier, Will Scudder, Maxwell Wray, Stephan Zuchner, Uwe Strahle, Ravindra Peravali, and Julia E. Dallman
    Chapter Eleven: The Mouse as a Model Organism for Assessing Anesthetic Sensitivity / Andrzej Z. Wasilczuk, Kaitlyn L. Maier, Max B. Kelz
    Chapter Twelve: Identification of General Anesthetic Target Protein-Binding Sites by Photoaffinity Labeling and Mass Spectrometry / Kellie A. Woll, William P. Dailey, Roderic G. Eckenhoff
    Chapter Thirteen: Xenon-Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR / Benjamin W. Roose, Serge D. Zemerov, Ivan J. Dmochowski
    Chapter Fourteen: Methods for Defining the Neuroprotective Properties of Xenon / Richie Robel, Peter Caroccio, Mervyn Maze
    Chapter Fifteen: Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration / Andrew McKinstry-Wu, Charles W. Carspecken, Alex Proekt, Max B. Kelz
    Chapter Sixteen: Native System and Cultured Cell Electrophysiology for Investigating Anesthetic Mechanisms / Paul Hoerbelt, Boris D. Heifets
    Chapter Seventeen: Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics / Elaine Yang, Lianteng Zhi, Qiansheng Liang, Manuel Covarrubias
    Chapter Eighteen: Combining Mutations and Electrophysiology to Map Anesthetic Sites on Ligand-Gated Ion Channels / Stuart A. Forman
    Chapter Nineteen: HCN and K2P Channels in Anesthetic Mechanisms Research / Paul M. Riegelhaupt, Gareth R. Tibbs, Peter A. Goldstein. Part B: Chapter One: Structural Analysis of Anesthetics in Complex with Soluble Proteins / Patrick J. Loll
    Chapter Two: X-Ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels / Qiang Chen, Yan Xu, Pei Tang
    Chapter Three: Solution NMR Studies of Anesthetic Interactions with Ion Channels / Vasyl Bondarenko, Marta Wells, Yan Xu, Pei Tang
    Chapter Four: Time-Resolved Neutron Interferometry and the Mechanism of Electromechanical Coupling in Voltage-Gated Ion Channels / J. Kent Blasie
    Chapter Five: Fluorescent Anesthetics / Daniel J. Emerson, Ivan J. Dmochowski
    Chapter Six: Investigation of Anesthetic-Protein Interactions by a Thermodynamic Approach / Hasan Babazada, Renyu Liu
    Chapter Seven: Electron Spin Resonance (EPR) in Drosophila and General Anesthesia / Luca Turin, Efthimios M.C. Skoulakis
    Chapter Eight: Giant Plasma Membrane Vesicles: An Experimental Tool for Probing the Effects of Drugs and Other Conditions on Membrane Domain Stability / Zoe Gerstle, Rohan Desai, Sarah L. Veatch
    Chapter Nine: Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs / Megan McGrath, Douglas E. Raines
    Chapter Ten: Optoanesthesia: Use of Anesthetic Photolabels In Vivo / Andrew R. McKinstry-Wu, Max B. Kelz
    Chapter Eleven: Optogenetics and Chemogenetics / Ksenia Vlasov, Christa J. Van Dort, Ken Solt
    Chapter Twelve: Genetic Reporters of Neuronal Activity: c-Fos and G-CaMP6 / Andrew E. Hudson
    Chapter Thirteen: Genomics and Proteomic Techniques / Jonathan Z. Pan
    Chapter Fourteen: Neurochemistry of Anesthetic States / Ralph Lydic, Helen A. Baghdoyan, Amanda L. May
    Chapter Fifteen: Brief Introduction to Electroencephalography / Alex Proekt
    Chapter Sixteen: Using Positron Emission Tomography in Revealing the Mystery of General Anesthesia: Study Design Challenges and Opportunities / Harry Scheinin, Emilee C. Alkire, Annalotta Scheinin, Michael T. Alkire, Oskari Kantonen, and Jaakko Långsjö
    Chapter Seventeen: Brain Imaging Using Hyperpolarized 129Xe Magnetic Resonance Imaging / Simrun Chahal, Braedan R.J. Prete, Alanna Wade, Francis T. Hane, and Mitchell S. Albert.
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