Bookedited by Uwe Gottschalk.
Contents:
1. Downstream processing of monoclonal antibodies: current practices and future opportunities
2. The development of antibody purification technologies
3. Harvest and recovery of monoclonal antibodies: cell removal and clarification
4. Next-generation clarification technologies for the downstream processing of antibodies
5. Protein A-based affinity chromatography
6. Purification of human monoclonal antibodies: non-protein A strategies
7. Hydrophobic interaction chromatography for the purification of antibodies
8. Purification of monoclonal antibodies by mixed-mode chromatography
9. Advances in technology and process development for industrial-scale monoclonal antibody purification
10. Alternatives to packed-bed chromatography for antibody extraction and purification
11. Process-scale percipitation of impurities in mammalian cell culture broth
12. Charged ultrafiltration and microfiltration membranes for antibody purification
13. Disposable prepaced-bed chromatography for downstream purification: form, fit, function, and industry adoption
14. Integrated polishing steps for monoclonal antibody purification
15. Orthogonal virus clearance applications in monoclonal antibody production
16. Development of a platform process for the purification of therapeutic monoclonal antibodies
17. The evolution of platform technologies for the downstream processing of antibodies
18. Countercurrent chromatography for the purification of monoclonal antibodies, bispecific antibodies and antibody-drug conjugates
19. The evolution of continuous chromatography: from bulk chemicals to biopharma
20. Accelerated seamless antibody purification: simplicity is key
21. Process economic drivers in industrial monoclonal antibody manufacture
22. Design and optimization of manufacturing
23. Smart design for an efficient facility with a validated disposable system
24. High-throughput screening and modeling technologies for process development in antibody purification
25. Downstream processing of monoclonal antibody fragments
26. Downstream processing Fc fusion proteins bispecific antibodies, and antibody-drug conjugates
27. Manufacturing concepts for antibody-drug conjugates
28. Purification of IgM and IgA
29. Purification of monoclonal antibodies from plants
30. Very-large-scale production of monoclonal antibodies in plants
31. Trends in formulation and drug delviery for antibodies
32. Antibody purification: drivers of change.